# Growth-Hormone Axis & Circadian Signalling Research SLEEP & REGENERATION — RESEARCH COMPOUNDS # Slow-wave sleep is where much of the interesting endocrinology happens. Super Relax PM, CJC-1295 with DAC, Sermorelin and DSIP — compounds studied in the context of sleep architecture and growth hormone signalling. [Bundle & Save 20% →](https://portaltowellness.net/shop/sleep-regeneration-stack/) [View Individual Compounds](https://portaltowellness.net/shop/sleep-regeneration-stack/) ✓ Save 20% — $43.76 off when you buy these together 📦 Ships in 1–2 Business Days 📚 Published research linked per compound Why This Stack ## Why this research area draws attention. Most daily growth hormone release occurs during slow-wave sleep, and that release declines with age and with disrupted sleep architecture. Both observations are well described in the endocrinology literature and neither depends on any product. Growth hormone secretagogues are studied for how they interact with that pulsatile system: CJC-1295 with DAC and Sermorelin are growth hormone-releasing analogues studied for their effect on endogenous secretion, while Super Relax PM is a non-peptide sleep support formulation. DSIP comes from a different literature again — delta-wave sleep signalling — and a considerably thinner one. What the published work describes is the physiology, not an outcome anyone should expect. Compound Composition ## What’s in this stack. COMPOUND 01 Super Relax PM — 10ml vial Non-peptide sleep support formulation. Its constituents are studied in the sleep literature in relation to GABA signalling and sleep-onset latency. PTW makes no claim about what the formulation does. Retail: $29.70 $23.76 with bundle [Add This Only](?add-to-cart=707) COMPOUND 02 CJC-1295 with DAC — 5mg/vial Long-acting GHRH analogue. The Drug Affinity Complex binds albumin, extending half-life relative to non-DAC variants. Studied for its effect on endogenous GH secretion. Retail: $49.00 $39.20 with bundle [Add This Only](?add-to-cart=149) COMPOUND 03 Sermorelin — 10mg/vial Synthetic analogue of the first 29 amino acids of endogenous GHRH. Studied for GH release via the pituitary's own feedback pathway, which is why it appears in work concerned with physiological pulsatility. Retail: $48.00 $38.40 with bundle [Add This Only](?add-to-cart=713) COMPOUND 04 DSIP — 15mg/vial Delta sleep-inducing peptide. A nonapeptide isolated in the 1970s and named for the delta-wave EEG activity reported in the animals it was infused into. It sits in the sleep-architecture literature rather than the growth hormone one, which is why it does not duplicate the two secretagogues above. Retail: $92.12 $73.70 with bundle [Add This Only](?add-to-cart=110) Mechanisms ## What the published work describes. 1 #### Super Relax PM — Constituents and Sleep Literature A non-peptide formulation. The sleep literature it draws on concerns GABA signalling, sleep-onset latency and slow-wave sleep duration — well described independently of any product. PTW does not publish the formulation's composition as a claim about what it does. 2 #### CJC-1295 with DAC — GHRH Analogue Pharmacokinetics A synthetic GHRH analogue. Its Drug Affinity Complex binds albumin, substantially extending half-life compared with non-DAC variants. The published interest is in how that altered pharmacokinetic profile interacts with the pulsatile GH system — an open question, not a described outcome. 3 #### Sermorelin — Physiological GH Secretion Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous GHRH. It stimulates pituitary somatotrophs to release GH through the body's own negative-feedback pathway. It appears in work concerned with preserving physiological pulsatility for that reason. 4 #### DSIP — Delta-Wave Sleep Signalling DSIP was isolated from cerebral venous blood by Schoenenberger and Monnier in the 1970s and named for the increase in delta-wave EEG activity observed in the animals it was infused into. The literature since is thinner and less settled than that of the GHRH analogues: no receptor has been definitively identified, and findings on sleep latency and EEG spectra have not been consistently reproduced. It is included here because it addresses sleep signalling directly rather than through the somatotropic axis — and the honest description of it is an open question, not an established mechanism. **Research Note:** Portal to Wellness does not publish administration guidance. We do not provide dosing, routes, schedules, cycling or combination advice, and we cannot answer questions about use in humans or animals. Published trial and preclinical literature is where pharmacokinetic and administration data belongs; the compound pages below link the primary sources. Bundle Pricing ## Save 20% when you buy these together. Sleep & Regeneration Kit — all four compounds Super Relax PM — 10ml vial $23.76 CJC-1295 with DAC — 5mg/vial $39.20 Sermorelin — 10mg/vial $38.40 DSIP — 15mg/vial $73.70 Bundle Total $175.06 You save $43.76 vs. buying them separately ($218.82) [Sleep & Regeneration Kit — all four compounds →](https://portaltowellness.net/shop/sleep-regeneration-stack/) Bundle pricing applied automatically at checkout. Each compound is also available individually. All products on Portal to Wellness are sold for research purposes only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm that you are a qualified researcher. ### Backed by the Research Research on These Compounds [DSIP & Epithalon: What the Research Says About Sleep and Circadian Peptides](https://portaltowellness.net/research/dsip-epithalon-what-the-research-says-about-sleep-and-circadian-peptides/) [Longevity Research 101: Compound Classes by Biological System](https://portaltowellness.net/research/longevity-research-101-compound-classes-by-biological-system/) Shop the Compounds [Super Relax PM – 10ml vial](https://portaltowellness.net/shop/super-relax-pm/) [CJC-1295 with DAC – 5mg/vial](https://portaltowellness.net/shop/cjc-1295-dac-5mg-vial/) [Sermorelin – 10mg/vial](https://portaltowellness.net/shop/sermorelin/) [DSIP – 15mg/vial](https://portaltowellness.net/shop/dsip/) More Research [Browse the full PTW Research Hub →](https://portaltowellness.net/research/) --- Source: https://portaltowellness.net/circadian-regulation-kit/ Research use only. 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