{"id":266,"date":"2025-12-31T12:03:45","date_gmt":"2025-12-31T18:03:45","guid":{"rendered":""},"modified":"2026-08-30T21:27:21","modified_gmt":"2026-08-31T03:27:21","slug":"glossary-sirtuin-pathways","status":"publish","type":"page","link":"https:\/\/portaltowellness.net\/es\/glossary-sirtuin-pathways\/","title":{"rendered":"Glosario: V\u00edas de las Sirtuinas"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><p><strong>Definici\u00f3n:<\/strong> Las sirtuinas son una familia de deacetilasas dependientes de NAD+ (SIRT1\u2013SIRT7) que regulan la expresi\u00f3n g\u00e9nica, el metabolismo y las respuestas al estr\u00e9s mediante la eliminaci\u00f3n de grupos acetilo de las histonas y otras prote\u00ednas.<\/p>\n<p><strong>Descripci\u00f3n general de la investigaci\u00f3n:<\/strong> Los estudios de las v\u00edas de las sirtuinas investigan c\u00f3mo estas enzimas influyen en la biog\u00e9nesis mitocondrial, la salud metab\u00f3lica, el envejecimiento, la inflamaci\u00f3n y la resiliencia celular al estr\u00e9s. Los investigadores examinan c\u00f3mo la activaci\u00f3n o inhibici\u00f3n de sirtuinas espec\u00edficas modula v\u00edas como AMPK, mTOR y FOXO, as\u00ed como sus funciones en la longevidad, la neuroprotecci\u00f3n y la regulaci\u00f3n metab\u00f3lica.<\/p>\n<p><strong>Aplicaciones en investigaci\u00f3n:<\/strong><\/p>\n<ul>\n<li>Exploraci\u00f3n de los mecanismos moleculares de la extensi\u00f3n de la vida \u00fatil y los mim\u00e9ticos de la restricci\u00f3n cal\u00f3rica<\/li>\n<li>Investigaci\u00f3n del v\u00ednculo entre la actividad de las sirtuinas, los trastornos metab\u00f3licos y las v\u00edas inflamatorias<\/li>\n<li>Desarrollo de moduladores de SIRT1-7 para estudios in vitro de enfermedades neurodegenerativas, c\u00e1ncer y s\u00edndrome metab\u00f3lico<\/li>\n<li>Comprensi\u00f3n de la interacci\u00f3n entre la se\u00f1alizaci\u00f3n de las sirtuinas, la autofagia y la funci\u00f3n mitocondrial<\/li>\n<\/ul>\n<p><strong>Solo para uso en investigaci\u00f3n:<\/strong> Esta p\u00e1gina tiene fines educativos y de discusi\u00f3n cient\u00edfica. Los materiales mencionados est\u00e1n destinados exclusivamente a la investigaci\u00f3n en laboratorio y no son para consumo humano ni animal.<\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>Glosario: V\u00edas de las Sirtuinas<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-266","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/pages\/266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=266"}],"version-history":[{"count":3,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/pages\/266\/revisions"}],"predecessor-version":[{"id":7170,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/pages\/266\/revisions\/7170"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}