{"id":110,"date":"2025-11-02T14:49:32","date_gmt":"2025-11-02T20:49:32","guid":{"rendered":"https:\/\/portaltowellness.net\/?post_type=product&#038;p=110"},"modified":"2026-10-09T09:24:09","modified_gmt":"2026-10-09T14:24:09","slug":"dsip","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/dsip\/","title":{"rendered":"DSIP \u2013 15mg\/vial (Solo para uso en investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><h3 style=\"color: #1a7a6e;margin-top: 20px\">Descripci\u00f3n general<\/h3>\n<p>El p\u00e9ptido inductor del sue\u00f1o delta (DSIP, por sus siglas en ingl\u00e9s) es un neurop\u00e9ptido de 9 amino\u00e1cidos de origen natural, aislado originalmente por Marcel Monnier a partir del perfusado tal\u00e1mico con capacidad para inducir el sue\u00f1o de ondas lentas (delta) en conejos. Desde su descubrimiento y caracterizaci\u00f3n en la d\u00e9cada de 1970, el DSIP ha acumulado una amplia base de investigaci\u00f3n publicada que abarca biolog\u00eda del sue\u00f1o, regulaci\u00f3n neuroendocrina, modulaci\u00f3n de la respuesta al estr\u00e9s e investigaci\u00f3n sobre mecanismos antioxidantes. Sus interacciones con m\u00faltiples sistemas de neurotransmisores \u2014incluyendo las v\u00edas opioid\u00e9rgica, serotonin\u00e9rgica y glutamat\u00e9rgica\u2014, junto con datos publicados sobre la modulaci\u00f3n de LH, somatostatina y ACTH, han convertido al DSIP en un sujeto de investigaci\u00f3n extraordinariamente multifac\u00e9tico dentro de la neurociencia.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">\u00bfQu\u00e9 es?<\/h3>\n<p>El DSIP (p\u00e9ptido inductor del sue\u00f1o delta) es un nonap\u00e9ptido con la secuencia Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, peso molecular aproximado de 849 Da, n\u00famero CAS 62568-57-4. A pesar de su peque\u00f1o tama\u00f1o, la investigaci\u00f3n publicada ha reportado que el DSIP es capaz de atravesar la barrera hematoencef\u00e1lica y es detectable en sangre perif\u00e9rica, l\u00edquido cefalorraqu\u00eddeo y m\u00faltiples \u00f3rganos perif\u00e9ricos. Sus efectos neuroendocrinos descritos en la literatura incluyen la modulaci\u00f3n de la liberaci\u00f3n de LH, la secreci\u00f3n de ACTH, la secreci\u00f3n de somatostatina y la corticosterona basal, con trabajos adicionales publicados sobre la actividad de enzimas antioxidantes y propiedades protectoras frente al estr\u00e9s en modelos animales.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Aplicaciones clave en investigaci\u00f3n<\/h3>\n<ul>\n<li>Investigaci\u00f3n sobre arquitectura del sue\u00f1o, inducci\u00f3n del sue\u00f1o de ondas lentas (delta) y endpoints de EEG<\/li>\n<li>Modulaci\u00f3n del eje hipot\u00e1lamo-hipofisario \u2014 estudios de regulaci\u00f3n de LH, ACTH y somatostatina<\/li>\n<li>Investigaci\u00f3n sobre interacciones del neurop\u00e9ptido con las v\u00edas opioid\u00e9rgica, serotonin\u00e9rgica y glutamat\u00e9rgica<\/li>\n<li>Atenuaci\u00f3n de la respuesta al estr\u00e9s y modulaci\u00f3n del eje HPA en modelos animales<\/li>\n<li>Estudios de actividad de enzimas antioxidantes (SOD, catalasa) y biomarcadores de estr\u00e9s oxidativo<\/li>\n<li>Investigaci\u00f3n sobre penetraci\u00f3n de la barrera hematoencef\u00e1lica y acceso de neurop\u00e9ptidos al SNC<\/li>\n<li>Investigaci\u00f3n sobre biolog\u00eda circadiana y p\u00e9ptidos reguladores del ciclo sue\u00f1o-vigilia<\/li>\n<li>Farmacolog\u00eda comparativa de p\u00e9ptidos del sue\u00f1o frente a otros moduladores end\u00f3genos del sue\u00f1o<\/li>\n<\/ul>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Especificaciones t\u00e9cnicas<\/h3>\n<table style=\"width: 100%;border-collapse: collapse;margin: 10px 0\">\n<tbody>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Amino\u00e1cidos<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">9 (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Peso molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">~849 Da<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">N\u00famero CAS<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">62568-57-4<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Pureza<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u226598% (especificaci\u00f3n del proveedor)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Forma<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Polvo liofilizado<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Tama\u00f1o del vial<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">15mg<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Almacenamiento<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u22124 \u00b0F a largo plazo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"background: #fff8e7;border-top: 2px solid #d4a017;border-bottom: 2px solid #d4a017;padding: 10px;margin-top: 20px\"><strong>SOLO PARA USO EN INVESTIGACI\u00d3N.<\/strong> No est\u00e1 destinado al consumo humano ni veterinario, ni al diagn\u00f3stico m\u00e9dico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n. Este producto no ha sido evaluado por la FDA ni por ning\u00fan organismo regulador. Debe ser manipulado por personal de investigaci\u00f3n calificado en un entorno de laboratorio conforme a la normativa vigente. Estas declaraciones no han sido evaluadas por la Administraci\u00f3n de Alimentos y Medicamentos de los Estados Unidos.<\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo sabes qu\u00e9 compuestos se ajustan a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Hub de Investigaci\u00f3n \u2192<\/a><\/p>\n<p><!-- PTW-RESEARCH-LINKS --><\/p>\n<h3>Investigaci\u00f3n relacionada (educativa)<\/h3>\n<ul>\n<li><a href=\"https:\/\/portaltowellness.net\/research\/dsip-epithalon-what-the-research-says-about-sleep-and-circadian-peptides\/\">DSIP y Epithalon: lo que dice la investigaci\u00f3n sobre p\u00e9ptidos del sue\u00f1o y circadianos<\/a><\/li>\n<li><a href=\"https:\/\/portaltowellness.net\/research\/sleep-repair-energy-one-system\/\">V\u00edas superpuestas en biolog\u00eda circadiana, de reparaci\u00f3n y mitocondrial<\/a><\/li>\n<\/ul>\n<div class=\"ptw-regulatory-note\" style=\"background:#fff8f0;border-left:3px solid #b45309;padding:16px 20px;margin-top:24px;border-radius:4px\">\n<p style=\"margin:0 0 8px;font-weight:600;font-size:14px;text-transform:uppercase;letter-spacing:.05em;color:#b45309\">Nota sobre estatus regulatorio<\/p>\n<p style=\"margin:0 0 8px\">Los d\u00edas 23 y 24 de julio de 2026, el Comit\u00e9 Asesor de Composici\u00f3n Farmac\u00e9utica de la FDA revis\u00f3 si BPC-157, TB-500, KPV, MOTS-c, Semax, Epitalon y emideltida (DSIP) deb\u00edan a\u00f1adirse a la Lista de Materiales a Granel 503A para la elaboraci\u00f3n magistral en farmacias. El comit\u00e9 vot\u00f3 a favor de recomendar seis de los siete compuestos; la emideltida (DSIP) <strong>no<\/strong> fue recomendada. Los propios documentos de informaci\u00f3n de la FDA hab\u00edan recomendado no incluir los siete.<\/p>\n<p style=\"margin:0\">El voto de un comit\u00e9 es \u00fanicamente una recomendaci\u00f3n. No constituye aprobaci\u00f3n de la FDA, no establece seguridad ni eficacia, y no modifica el estatus de este producto, el cual se vende estrictamente para uso en investigaci\u00f3n. La FDA debe completar un proceso formal de regulaci\u00f3n antes de que cualquier sustancia sea a\u00f1adida a la lista. <a href=\"https:\/\/www.fda.gov\/advisory-committees\/advisory-committee-calendar\/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026\" rel=\"nofollow noopener\" target=\"_blank\">Fuente: Calendario del Comit\u00e9 Asesor de la FDA<\/a>. \u00daltima revisi\u00f3n: 17 de agosto de 2026.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>P\u00e9ptido inductor del sue\u00f1o delta, un nonap\u00e9ptido investigado en publicaciones cient\u00edficas por su interacci\u00f3n con la arquitectura del sue\u00f1o de ondas lentas y la se\u00f1alizaci\u00f3n neuroendocrina en modelos animales. Suministrado exclusivamente para investigaci\u00f3n en laboratorio e identificaci\u00f3n.<\/p>","protected":false},"featured_media":1114,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"","ptw_coa_url":"","ptw_science_overview":"","ptw_science_research":"","ptw_science_stack":"","_ptw_batch_number":""},"product_brand":[35],"product_cat":[550],"product_tag":[429,51,430,234],"class_list":["post-110","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-hormone-circadian","product_tag-injectable","product_tag-recovery","product_tag-research","product_tag-sleep","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=110"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/1114"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=110"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=110"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=110"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}