{"id":112,"date":"2025-11-02T14:50:10","date_gmt":"2025-11-02T20:50:10","guid":{"rendered":"https:\/\/portaltowellness.net\/?post_type=product&#038;p=112"},"modified":"2026-10-09T09:18:24","modified_gmt":"2026-10-09T14:18:24","slug":"ll37","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/ll37\/","title":{"rendered":"LL37 \u2013 5mg\/vial (Solo para uso en investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><h3 style=\"color: #1a7a6e;margin-top: 20px\">Descripci\u00f3n general<\/h3>\n<p>LL-37 es el \u00fanico miembro de la familia de p\u00e9ptidos de defensa del hu\u00e9sped catelicidinas expresado en humanos, escindido del extremo C-terminal de la prote\u00edna precursora hCAP18 (prote\u00edna antimicrobiana cati\u00f3nica humana 18). Como principal catelicidina humana, LL-37 ha generado una extensa investigaci\u00f3n publicada en farmacolog\u00eda antimicrobiana, inmunomodulaci\u00f3n, biolog\u00eda de cicatrizaci\u00f3n de heridas, angiog\u00e9nesis y biolog\u00eda del c\u00e1ncer. Sus roles duales como agente antimicrobiano directo y mol\u00e9cula de se\u00f1alizaci\u00f3n inmunomoduladora \u2014actuando sobre FPR2\/FPRL1, P2X7 y el receptor EGF, entre otros blancos moleculares\u2014 lo convierten en uno de los p\u00e9ptidos de investigaci\u00f3n mecan\u00edsticamente m\u00e1s vers\u00e1tiles en inmunidad innata.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">\u00bfQu\u00e9 es?<\/h3>\n<p>LL-37 es un p\u00e9ptido anfip\u00e1tico de h\u00e9lice alfa compuesto por 37 amino\u00e1cidos con la secuencia N-terminal LL (Leu-Leu), escindido de la regi\u00f3n C-terminal de hCAP18 por procesamiento de serina proteasa (proteinasa 3). F\u00f3rmula molecular: C\u2082\u2080\u2085H\u2083\u2084\u2080N\u2086\u2080O\u2085\u2083S (aproximada), PM aproximado de 4,493 Da, n\u00famero CAS 154947-66-7. Su estructura de h\u00e9lice alfa anfip\u00e1tica permite la disrupci\u00f3n de membranas lip\u00eddicas bacterianas, f\u00fangicas y virales, al tiempo que interact\u00faa con receptores de superficie de c\u00e9lulas eucariotas, incluyendo FPR2\/FPRL1, EGFR y el receptor purin\u00e9rgico P2X7.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Principales aplicaciones de investigaci\u00f3n<\/h3>\n<ul>\n<li>Investigaci\u00f3n de actividad antimicrobiana \u2014 estudios de disrupci\u00f3n de membrana bacteriana y CMI<\/li>\n<li>Biolog\u00eda de p\u00e9ptidos de defensa del hu\u00e9sped e investigaci\u00f3n en inmunidad innata<\/li>\n<li>Estudios de activaci\u00f3n de receptores FPR2\/FPRL1 y EGFR, y se\u00f1alizaci\u00f3n corriente abajo<\/li>\n<li>Investigaci\u00f3n en cicatrizaci\u00f3n de heridas \u2014 estudios de migraci\u00f3n y proliferaci\u00f3n de c\u00e9lulas epiteliales y angiog\u00e9nesis<\/li>\n<li>Investigaci\u00f3n de actividad anti-biopel\u00edcula y mecanismos de resistencia antibacteriana<\/li>\n<li>Investigaci\u00f3n de v\u00edas inmunomoduladoras \u2014 activaci\u00f3n de macr\u00f3fagos, c\u00e9lulas dendr\u00edticas y neutr\u00f3filos<\/li>\n<li>Biolog\u00eda del c\u00e1ncer \u2014 investigaci\u00f3n del efecto dual pro-apopt\u00f3tico y pro-supervivencia de LL-37<\/li>\n<li>Estudios de mecanismos antivirales \u2014 investigaci\u00f3n de la interacci\u00f3n con membranas de virus envueltos<\/li>\n<\/ul>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Especificaciones t\u00e9cnicas<\/h3>\n<table style=\"width: 100%;border-collapse: collapse;margin: 10px 0\">\n<tbody>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Amino\u00e1cidos<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">37 (secuencia N-terminal Leu-Leu)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Peso molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">~4,493 Da<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">N\u00famero CAS<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">154947-66-7<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Origen<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Producto del gen CAMP de catelicidina humana (fragmento C-terminal de hCAP18)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Mecanismo<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Disruptor de membrana antimicrobiano; agonista de FPR2\/FPRL1 y EGFR<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Pureza<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u226598% (especificaci\u00f3n del proveedor)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Presentaci\u00f3n<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Polvo liofilizado<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Tama\u00f1o del vial<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">5mg<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Almacenamiento<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u22124 \u00b0F a largo plazo; evita ciclos repetidos de congelaci\u00f3n y descongelaci\u00f3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"background: #fff8e7;border-top: 2px solid #d4a017;border-bottom: 2px solid #d4a017;padding: 10px;margin-top: 20px\"><strong>SOLO PARA USO EN INVESTIGACI\u00d3N.<\/strong> No est\u00e1 destinado al consumo humano ni veterinario, ni al diagn\u00f3stico m\u00e9dico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n. Este producto no ha sido evaluado por la FDA ni por ninguna agencia regulatoria. Debe ser manejado por personal de investigaci\u00f3n calificado en un entorno de laboratorio que cumpla con la normativa aplicable. Estas declaraciones no han sido evaluadas por la Administraci\u00f3n de Alimentos y Medicamentos de los Estados Unidos.<\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo est\u00e1s seguro de qu\u00e9 compuestos se adaptan a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Centro de Investigaci\u00f3n \u2192<\/a><\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>LL-37, el p\u00e9ptido humano de defensa del hu\u00e9sped catelicidina, estudiado en investigaci\u00f3n de inmunidad innata, p\u00e9ptidos antimicrobianos y biolog\u00eda de heridas. Suministrado \u00fanicamente con fines de investigaci\u00f3n de laboratorio e identificaci\u00f3n.<\/p>","protected":false},"featured_media":1113,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"","ptw_coa_url":"","ptw_science_overview":"","ptw_science_research":"","ptw_science_stack":"","_ptw_batch_number":""},"product_brand":[35],"product_cat":[522,519],"product_tag":[490,429,430],"class_list":["post-112","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-immune-modulators","product_cat-recovery-repair","product_tag-antimicrobial","product_tag-injectable","product_tag-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=112"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/1113"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=112"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=112"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=112"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}