{"id":147,"date":"2025-11-04T02:20:17","date_gmt":"2025-11-04T08:20:17","guid":{"rendered":"https:\/\/portaltowellness.net\/?post_type=product&#038;p=147"},"modified":"2026-10-22T20:02:10","modified_gmt":"2026-10-23T01:02:10","slug":"semax-10mg-vial","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/semax-10mg-vial\/","title":{"rendered":"Semax \u2013 10mg\/vial (Solo para uso en investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><h3 style=\"color: #1a7a6e;margin-top: 20px\">Descripci\u00f3n general<\/h3>\n<p>Semax es un heptap\u00e9ptido nootr\u00f3pico sint\u00e9tico desarrollado en el Instituto de Gen\u00e9tica Molecular de la Academia de Ciencias de Rusia, basado en el fragmento central ACTH(4-10) extendido con un trip\u00e9ptido C-terminal Pro-Gly-Pro para mejorar la estabilidad metab\u00f3lica. Originalmente estudiado para aplicaciones cerebrovasculares y neuroprotectoras, Semax ha generado una base de investigaci\u00f3n publicada que abarca la regulaci\u00f3n positiva de BDNF, la modulaci\u00f3n de los sistemas dopamin\u00e9rgico y serotonin\u00e9rgico, la investigaci\u00f3n sobre isquemia-reperfusi\u00f3n y estudios de biomarcadores de funci\u00f3n cognitiva en modelos de roedores. Cuenta con aprobaci\u00f3n regulatoria en Rusia y Ucrania como f\u00e1rmaco pept\u00eddico nootr\u00f3pico.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">\u00bfQu\u00e9 es?<\/h3>\n<p>Semax es un heptap\u00e9ptido con la secuencia Met-Glu-His-Phe-Pro-Gly-Pro, PM aproximadamente 779 Da, n\u00famero CAS 80714-61-0. Es un an\u00e1logo estructural de ACTH(4-7) (Met-Glu-His-Phe) con la extensi\u00f3n C-terminal Pro-Gly-Pro tomada del programa de investigaci\u00f3n de Selank para conferir estabilidad enzim\u00e1tica. Semax no se une a los receptores de melanocortina en concentraciones farmacol\u00f3gicamente relevantes, pero la investigaci\u00f3n publicada ha demostrado que regula positivamente la expresi\u00f3n de BDNF y NGF, modula marcadores del sistema dopamin\u00e9rgico y afecta la actividad del transportador de serotonina.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Aplicaciones clave en investigaci\u00f3n<\/h3>\n<ul>\n<li>Investigaci\u00f3n sobre regulaci\u00f3n positiva de BDNF y NGF en tejido cortical e hipocampal<\/li>\n<li>Investigaci\u00f3n cerebrovascular \u2014 modelado de lesi\u00f3n por isquemia-reperfusi\u00f3n y neuroprotecci\u00f3n<\/li>\n<li>Modulaci\u00f3n del sistema dopamin\u00e9rgico y estudios de expresi\u00f3n de receptores D1\/D2<\/li>\n<li>Investigaci\u00f3n del transportador de serotonina (SERT) y se\u00f1alizaci\u00f3n serotonin\u00e9rgica<\/li>\n<li>Estudios de biomarcadores de funci\u00f3n cognitiva y consolidaci\u00f3n de memoria en modelos de roedores<\/li>\n<li>Farmacolog\u00eda de fragmentos de ACTH sin activaci\u00f3n adrenocortical<\/li>\n<li>Farmacolog\u00eda comparativa de p\u00e9ptidos nootr\u00f3picos frente a Selank y otros p\u00e9ptidos derivados de ACTH<\/li>\n<li>Estudios precl\u00ednicos de modelado de accidente cerebrovascular, lesi\u00f3n cerebral traum\u00e1tica e hipoxia<\/li>\n<\/ul>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Especificaciones t\u00e9cnicas<\/h3>\n<table style=\"width: 100%;border-collapse: collapse;margin: 10px 0\">\n<tbody>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Amino\u00e1cidos<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">7 (Met-Glu-His-Phe-Pro-Gly-Pro)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Peso molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">~779 Da<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">N\u00famero CAS<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">80714-61-0<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Estructura base<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">ACTH(4-7) + extensi\u00f3n Pro-Gly-Pro<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Pureza<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u226598% (especificaci\u00f3n del proveedor)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Forma<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Polvo liofilizado<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Tama\u00f1o del vial<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">10mg<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Almacenamiento<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u22124 \u00b0F a largo plazo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"background: #fff8e7;border-top: 2px solid #d4a017;border-bottom: 2px solid #d4a017;padding: 10px;margin-top: 20px\"><strong>SOLO PARA USO EN INVESTIGACI\u00d3N.<\/strong> No est\u00e1 destinado al consumo humano ni veterinario, ni al diagn\u00f3stico m\u00e9dico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n. Este producto no ha sido evaluado por la FDA ni por ninguna agencia regulatoria. Debe ser manipulado por personal de investigaci\u00f3n calificado en un entorno de laboratorio que cumpla con la normativa aplicable. Estas declaraciones no han sido evaluadas por la Administraci\u00f3n de Alimentos y Medicamentos de los Estados Unidos.<\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo sabes qu\u00e9 compuestos se ajustan a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Centro de Investigaci\u00f3n \u2192<\/a><\/p>\n<div class=\"ptw-regulatory-note\" style=\"background:#fff8f0;border-left:3px solid #b45309;padding:16px 20px;margin-top:24px;border-radius:4px\">\n<p style=\"margin:0 0 8px;font-weight:600;font-size:14px;text-transform:uppercase;letter-spacing:.05em;color:#b45309\">Nota sobre estatus regulatorio<\/p>\n<p style=\"margin:0 0 8px\">El 23 y 24 de julio de 2026, el Comit\u00e9 Asesor de Compuestos Farmac\u00e9uticos de la FDA revis\u00f3 si BPC-157, TB-500, KPV, MOTS-c, Semax, Epitalon y emideltida (DSIP) deb\u00edan a\u00f1adirse a la Lista de Materias a Granel 503A para la preparaci\u00f3n magistral. El comit\u00e9 vot\u00f3 a favor de recomendar seis de los siete; la emideltida (DSIP) <strong>no<\/strong> fue recomendada. Los propios documentos de presentaci\u00f3n de la FDA hab\u00edan recomendado en contra de los siete.<\/p>\n<p style=\"margin:0\">El voto de un comit\u00e9 es \u00fanicamente una recomendaci\u00f3n. No constituye aprobaci\u00f3n de la FDA, no establece seguridad ni efectividad, y no cambia el estatus de este producto, el cual se vende estrictamente para uso en investigaci\u00f3n. La FDA debe completar un proceso formal de reglamentaci\u00f3n antes de que cualquier sustancia sea a\u00f1adida a la lista. <a href=\"https:\/\/www.fda.gov\/advisory-committees\/advisory-committee-calendar\/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026\" rel=\"nofollow noopener\" target=\"_blank\">Fuente: Calendario del Comit\u00e9 Asesor de la FDA<\/a>. \u00daltima revisi\u00f3n: 17 de agosto de 2026.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Semax, un heptap\u00e9ptido sint\u00e9tico basado en un fragmento de ACTH, estudiado en investigaci\u00f3n sobre neurotrofinas (BDNF\/NGF) y se\u00f1alizaci\u00f3n de melanocortina. Suministrado solo para investigaci\u00f3n de laboratorio y fines de identificaci\u00f3n.<\/p>","protected":false},"featured_media":1103,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"Studied for BDNF and NGF gene expression in hippocampus and prefrontal cortex models|Developed at the Russian Academy of Sciences; studied in ischaemic stroke recovery|No stimulant mechanism or receptor downregulation documented in the published literature|Derived from the ACTH(4\u20137) sequence with a C-terminal Pro-Gly-Pro extension for metabolic stability|No receptor competition with other research peptides documented","ptw_coa_url":"","ptw_science_overview":"Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4\u20137) sequence, modified with a proline-glycine-proline C-terminal extension for metabolic stability. Published work reports upregulation of BDNF and NGF gene expression in the hippocampus and prefrontal cortex, effects on dopaminergic and serotonergic neurotransmission, and neuroprotective effects against ischaemic and oxidative stress. The Pro-Gly-Pro extension confers resistance to enzymatic degradation.","ptw_science_research":"Clinical studies in Russia evaluated Semax in acute ischaemic stroke recovery, reporting changes in neurological deficit scores versus placebo. Cognitive studies report effects on attention, working memory and processing speed. BDNF upregulation has been observed within hours of administration, with expression reported to persist for several days. This body of work has limited independent replication outside Russia.","ptw_science_stack":"Semax and Selank are frequently examined together in the published cognitive literature, acting on different pathways. No receptor competition with longevity or metabolic research compounds is documented.","_ptw_batch_number":""},"product_brand":[35],"product_cat":[507,510],"product_tag":[442,429,231,232,430],"class_list":["post-147","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-neuropeptides","product_cat-best-sellers","product_tag-cognitive","product_tag-injectable","product_tag-neuropeptide","product_tag-nootropic","product_tag-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/1103"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=147"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=147"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=147"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}