{"id":160,"date":"2025-11-04T12:35:52","date_gmt":"2025-11-04T18:35:52","guid":{"rendered":"https:\/\/portaltowellness.net\/?post_type=product&#038;p=160"},"modified":"2026-10-09T09:15:39","modified_gmt":"2026-10-09T14:15:39","slug":"ara-290-10mg-vial","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/ara-290-10mg-vial\/","title":{"rendered":"ARA-290 \u2013 10mg\/vial (Solo para Uso en Investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><h3 style=\"color: #1a7a6e;margin-top: 20px\">Descripci\u00f3n general<\/h3>\n<p>ARA-290 (tambi\u00e9n conocido como Cibinetide) es un p\u00e9ptido sint\u00e9tico de 11 amino\u00e1cidos basado en la regi\u00f3n H\u00e9lice B de la eritropoyetina (EPO), dise\u00f1ado espec\u00edficamente para activar el receptor de reparaci\u00f3n innata (IRR, compuesto por el homod\u00edmero del receptor de EPO o el heterorreceptor tisular protector con CD131\/\u03b2c), evitando al mismo tiempo el receptor hematopoy\u00e9tico de eritropoyetina (homod\u00edmero EPOR). Este enfoque de ingenier\u00eda molecular ha permitido a los investigadores estudiar los efectos no hematopoy\u00e9ticos de la EPO para la protecci\u00f3n tisular \u2014en modelos neurol\u00f3gicos, metab\u00f3licos e inflamatorios\u2014 de forma independiente a su actividad estimulante de gl\u00f3bulos rojos, proporcionando una herramienta mecan\u00edstica importante para diseccionar la biolog\u00eda del receptor de EPO.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Qu\u00e9 es<\/h3>\n<p>ARA-290 es un p\u00e9ptido lineal de 11 amino\u00e1cidos derivado de la superficie H\u00e9lice B de la EPO humana, con un peso molecular aproximado de 1,264 Da y n\u00famero CAS 1234356-69-4. Su secuencia corresponde a los residuos 58-82 de la EPO (H\u00e9lice B) y carece de los ep\u00edtopos de uni\u00f3n al homod\u00edmero EPOR necesarios para la eritropoyesis. Se une preferentemente al complejo del receptor de reparaci\u00f3n innata (heterod\u00edmero con CD131\/\u03b2c) en sitios tisulares perif\u00e9ricos y centrales, activando cascadas de se\u00f1alizaci\u00f3n citoprotectoras que incluyen PI3K\/Akt y NF-\u03baB sin estimular la hematopoyesis.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Principales aplicaciones de investigaci\u00f3n<\/h3>\n<ul>\n<li>Investigaci\u00f3n sobre la activaci\u00f3n del receptor de reparaci\u00f3n innata (IRR) y la se\u00f1alizaci\u00f3n tisular protectora de la EPO<\/li>\n<li>Biolog\u00eda del receptor de EPO no hematopoy\u00e9tico \u2014 estudios de las v\u00edas PI3K\/Akt y antiapopt\u00f3ticas<\/li>\n<li>Investigaci\u00f3n en dolor neurop\u00e1tico \u2014 estudios sobre neuropat\u00eda de fibras peque\u00f1as y densidad de fibras nerviosas corneales<\/li>\n<li>Modelado precl\u00ednico de neuropat\u00eda perif\u00e9rica e investigaci\u00f3n sobre regeneraci\u00f3n nerviosa<\/li>\n<li>Estudios sobre mecanismos de supresi\u00f3n de citocinas inflamatorias y citoprotecci\u00f3n tisular<\/li>\n<li>Modelado de complicaciones diab\u00e9ticas \u2014 investigaci\u00f3n sobre neuropat\u00eda perif\u00e9rica y retina<\/li>\n<li>Investigaci\u00f3n farmacol\u00f3gica sobre la selectividad homod\u00edmero vs. heterod\u00edmero (IRR) del receptor de EPO<\/li>\n<li>Modelado de sarcoidosis, neuropat\u00eda inflamatoria y enfermedades inflamatorias sist\u00e9micas<\/li>\n<\/ul>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Especificaciones t\u00e9cnicas<\/h3>\n<table style=\"width: 100%;border-collapse: collapse;margin: 10px 0\">\n<tbody>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Amino\u00e1cidos<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">11 (derivado de la H\u00e9lice B de EPO)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Peso molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">~1,264 Da<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">N\u00famero CAS<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">1234356-69-4<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Tambi\u00e9n conocido como<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Cibinetide; p\u00e9ptido de superficie H\u00e9lice B (HBSP)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Mecanismo<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Agonista del Receptor de Reparaci\u00f3n Innata (IRR) \u2014 no hematopoy\u00e9tico<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Pureza<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u226598% (especificaci\u00f3n del proveedor)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Forma<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Polvo liofilizado<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Tama\u00f1o del vial<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">10mg<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Almacenamiento<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u22124 \u00b0F a largo plazo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"background: #fff8e7;border-top: 2px solid #d4a017;border-bottom: 2px solid #d4a017;padding: 10px;margin-top: 20px\"><strong>SOLO PARA USO EN INVESTIGACI\u00d3N.<\/strong> No est\u00e1 destinado al consumo humano ni veterinario, ni al diagn\u00f3stico m\u00e9dico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n. Este producto no ha sido evaluado por la FDA ni por ning\u00fan organismo regulador. Debe ser manipulado por personal de investigaci\u00f3n calificado en un entorno de laboratorio adecuado. Estas declaraciones no han sido evaluadas por la Administraci\u00f3n de Alimentos y Medicamentos.<\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo sabes qu\u00e9 compuestos se adaptan a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Centro de Investigaci\u00f3n \u2192<\/a><\/p>\n<p><!-- PTW-RESEARCH-LINKS --><\/p>\n<h3>Investigaci\u00f3n relacionada (educativa)<\/h3>\n<ul>\n<li><a href=\"https:\/\/portaltowellness.net\/research\/recovery-repair-research-compounds-guide\/\">Compuestos de investigaci\u00f3n para recuperaci\u00f3n y reparaci\u00f3n: una gu\u00eda completa<\/a><\/li>\n<\/ul><\/div>","protected":false},"excerpt":{"rendered":"<p>ARA-290, un p\u00e9ptido de 11 amino\u00e1cidos derivado de la eritropoyetina, estudiado en investigaci\u00f3n de se\u00f1alizaci\u00f3n del receptor de reparaci\u00f3n innata (EPOR\/\u03b2cR). Suministrado \u00fanicamente para investigaci\u00f3n en laboratorio e identificaci\u00f3n.<\/p>","protected":false},"featured_media":1100,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"","ptw_coa_url":"","ptw_science_overview":"","ptw_science_research":"","ptw_science_stack":"","_ptw_batch_number":""},"product_brand":[35],"product_cat":[522,519],"product_tag":[429,483,430],"class_list":["post-160","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-immune-modulators","product_cat-recovery-repair","product_tag-injectable","product_tag-neuroprotective","product_tag-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=160"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/1100"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=160"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=160"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=160"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}