{"id":164,"date":"2025-11-14T00:56:07","date_gmt":"2025-11-14T06:56:07","guid":{"rendered":"https:\/\/portaltowellness.net\/?post_type=product&#038;p=164"},"modified":"2026-09-16T06:47:27","modified_gmt":"2026-09-16T11:47:27","slug":"5-amino-1mq-1","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/5-amino-1mq-1\/","title":{"rendered":"5-Amino-1MQ \u2013 50mg \u00d7 25pcs (Solo para Uso en Investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><p><!-- wp:html --><\/p>\n<p><style>.ptw-product-research-link{background:#f6f3ec;border:1px solid #e0d9c8;border-left:4px solid #8a7a4d;border-radius:8px;padding:14px 18px;margin:16px 0 20px;font-size:15px;}.ptw-product-research-link__label{display:block;font-size:11px;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:#8a7a4d;margin-bottom:6px;}.ptw-product-research-link__link{display:block;color:#1a2b4c;font-weight:600;text-decoration:underline;margin-top:3px;}<\/style><\/p>\n<p><!-- \/wp:html --><br \/><!-- wp:html --><\/p>\n<div class=\"ptw-product-research-link\"><span class=\"ptw-product-research-link__label\">Respaldado por la investigaci\u00f3n<\/span><a class=\"ptw-product-research-link__link\" href=\"https:\/\/portaltowellness.net\/research\/visceral-fat-metabolic-health-research\/\">Leer: Investigaci\u00f3n sobre grasa visceral y salud metab\u00f3lica \u2192<\/a><\/div>\n<p><!-- \/wp:html --><\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Descripci\u00f3n general<\/h3>\n<p>5-amino-1MQ (5-amino-1-metilquinolinio) es un inhibidor sint\u00e9tico de mol\u00e9cula peque\u00f1a de la nicotinamida N-metiltransferasa (NNMT), una enzima que cataliza la N-metilaci\u00f3n de la nicotinamida utilizando S-adenosilmetionina (SAM) como donador de grupos metilo. Al inhibir la NNMT, la investigaci\u00f3n con 5-amino-1MQ ha examinado los efectos sobre la disponibilidad celular de SAM, el metabolismo de un carbono, el ciclo de precursores de NAD+ y la biolog\u00eda de los adipocitos. La investigaci\u00f3n precl\u00ednica publicada ha examinado sus efectos sobre la adipog\u00e9nesis, el tama\u00f1o de los adipocitos, la acumulaci\u00f3n de l\u00edpidos y el gasto energ\u00e9tico en modelos de cultivo celular y en roedores, convirti\u00e9ndolo en una herramienta de investigaci\u00f3n para estudios de biolog\u00eda metab\u00f3lica y del tejido adiposo.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">\u00bfQu\u00e9 es?<\/h3>\n<p>5-amino-1MQ es un compuesto de mol\u00e9cula peque\u00f1a cargada (sal de amonio cuaternario) con la f\u00f3rmula molecular C\u2081\u2080H\u2081\u2081N\u2082\u207a (como el quinolinio metilado), con un PM aproximado de 159.21 Da (cati\u00f3n). Act\u00faa como inhibidor competitivo de la NNMT al ocupar el sitio de uni\u00f3n de la nicotinamida, reduciendo la capacidad de la enzima para consumir SAM y producir 1-metilnicotinamida (1-MNA). Esto preserva los dep\u00f3sitos de SAM para otras reacciones de metilaci\u00f3n y modifica la din\u00e1mica de los precursores de NAD+. N\u00famero CAS: 1392274-18-8.<\/p>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Principales aplicaciones de investigaci\u00f3n<\/h3>\n<ul>\n<li>Investigaci\u00f3n sobre la inhibici\u00f3n enzim\u00e1tica de la NNMT y la v\u00eda de transferencia de grupos metilo de un carbono<\/li>\n<li>Estudios sobre disponibilidad de SAM, capacidad de metilaci\u00f3n y regulaci\u00f3n epigen\u00e9tica<\/li>\n<li>Investigaci\u00f3n sobre adipog\u00e9nesis, acumulaci\u00f3n de l\u00edpidos en adipocitos y biolog\u00eda de las c\u00e9lulas grasas<\/li>\n<li>Estudios sobre bios\u00edntesis de NAD+, flujo de la v\u00eda de rescate y metabolismo de la nicotinamida<\/li>\n<li>Investigaci\u00f3n sobre el pardeamiento del tejido adiposo blanco y marcadores de termog\u00e9nesis<\/li>\n<li>Estudios de modelado precl\u00ednico de obesidad y s\u00edndrome metab\u00f3lico<\/li>\n<li>Expresi\u00f3n de NNMT en contextos de envejecimiento, c\u00e1ncer y enfermedad metab\u00f3lica<\/li>\n<li>Farmacolog\u00eda comparativa de inhibidores de NNMT y caracterizaci\u00f3n de selectividad<\/li>\n<\/ul>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Especificaciones t\u00e9cnicas<\/h3>\n<table style=\"width: 100%;border-collapse: collapse;margin: 10px 0\">\n<tbody>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Compuesto<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">5-Amino-1-metilquinolinio (5-amino-1MQ)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Peso molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">~159.21 Da (cati\u00f3n)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">N\u00famero CAS<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">1392274-18-8<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Mecanismo<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Inhibidor de NNMT (Nicotinamida N-Metiltransferasa)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Pureza<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u226598% (especificaci\u00f3n del proveedor)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Forma<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">C\u00e1psula oral (50 mg)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Cantidad<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">25 c\u00e1psulas por frasco<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Almacenamiento<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Temperatura ambiente, lejos de la humedad y la luz<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"background: #fff8e7;border-top: 2px solid #d4a017;border-bottom: 2px solid #d4a017;padding: 10px;margin-top: 20px\"><strong>SOLO PARA USO EN INVESTIGACI\u00d3N.<\/strong> No est\u00e1 destinado al consumo humano ni veterinario, ni al diagn\u00f3stico m\u00e9dico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n. Este producto no ha sido evaluado por la FDA ni por ning\u00fan organismo regulador. Debe ser manipulado por personal de investigaci\u00f3n calificado en un entorno de laboratorio adecuado. Estas declaraciones no han sido evaluadas por la Administraci\u00f3n de Alimentos y Medicamentos.<\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo sabes qu\u00e9 compuestos se adaptan mejor a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Centro de Investigaci\u00f3n \u2192<\/a><\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>5-Amino-1MQ, un inhibidor de mol\u00e9cula peque\u00f1a de la nicotinamida N-metiltransferasa (NNMT), estudiado en investigaci\u00f3n del metabolismo de la nicotinamida y NAD+. Suministrado \u00fanicamente para investigaci\u00f3n de laboratorio e identificaci\u00f3n.<\/p>","protected":false},"featured_media":165,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"","ptw_coa_url":"","ptw_science_overview":"","ptw_science_research":"","ptw_science_stack":"","_ptw_batch_number":""},"product_brand":[35],"product_cat":[520,521],"product_tag":[336,480,434,430],"class_list":["post-164","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-metabolic-research","product_cat-mitochondrial-longevity","product_tag-metabolic","product_tag-nnmt","product_tag-oral","product_tag-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=164"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/165"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=164"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=164"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=164"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}