{"id":705,"date":"2026-04-26T07:26:11","date_gmt":"2026-04-26T13:26:11","guid":{"rendered":"https:\/\/portaltowellness.net\/shop\/sirolimus-rapamycin\/"},"modified":"2026-09-16T06:47:27","modified_gmt":"2026-09-16T11:47:27","slug":"sirolimus-rapamycin","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/sirolimus-rapamycin\/","title":{"rendered":"Sirolimus (Rapamycin) \u2013 5mg \u00d7 10 tabletas (Solo para uso en investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><h3 style=\"color: #1a7a6e;margin-top: 20px\">Descripci\u00f3n general<\/h3>\nEl sirolimus (rapamicina) es uno de los compuestos m\u00e1s relevantes en la investigaci\u00f3n moderna sobre longevidad y biolog\u00eda celular. Aislado originalmente de la bacteria <em>Streptomyces hygroscopicus<\/em> descubierta en la Isla de Pascua (Rapa Nui), el sirolimus es el inhibidor protot\u00edpico de la v\u00eda mTOR (diana mecanicista de la rapamicina). El nodo de se\u00f1alizaci\u00f3n mTOR integra la detecci\u00f3n celular de nutrientes, las se\u00f1ales de factores de crecimiento y el estado energ\u00e9tico para regular la s\u00edntesis de prote\u00ednas, la autofagia y los programas de envejecimiento celular. La capacidad de la rapamicina para extender la vida \u00fatil en m\u00faltiples organismos modelo \u2014incluidos ratones\u2014 la ha convertido en el compuesto de referencia en la biolog\u00eda traslacional de la longevidad.\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">\u00bfQu\u00e9 es?<\/h3>\nEl sirolimus es un compuesto macr\u00f3lido (f\u00f3rmula molecular C\u2085\u2081H\u2087\u2089NO\u2081\u2083, PM ~914.17 Da, n\u00famero CAS 53123-88-9) que act\u00faa como inhibidor alost\u00e9rico de mTORC1 al formar un complejo de ganancia de funci\u00f3n con la prote\u00edna de uni\u00f3n a FK506 FKBP12. Este complejo FKBP12-rapamicina se une e inhibe la actividad quinasa de mTOR sobre S6K1 y 4E-BP1. El sirolimus cuenta con aprobaci\u00f3n de la FDA como inmunosupresor (Rapamune), lo que ha generado una amplia literatura cl\u00ednica sobre su farmacocin\u00e9tica en humanos.\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Principales aplicaciones de investigaci\u00f3n<\/h3>\n<ul>\n \t<li>Investigaci\u00f3n sobre la inhibici\u00f3n de la v\u00eda mTORC1 y la se\u00f1alizaci\u00f3n de detecci\u00f3n de nutrientes<\/li>\n \t<li>Estudios sobre inducci\u00f3n de autofagia, mitofagia y mecanismos de control de calidad celular<\/li>\n \t<li>Modelado de extensi\u00f3n de vida \u00fatil en sistemas de levaduras, <em>C. elegans<\/em>, <em>Drosophila<\/em> y roedores<\/li>\n \t<li>Investigaci\u00f3n en farmacolog\u00eda de la inmunosupresi\u00f3n e inhibici\u00f3n de la proliferaci\u00f3n de linfocitos T y B<\/li>\n \t<li>Estudios sobre mim\u00e9ticos de restricci\u00f3n cal\u00f3rica y v\u00edas de biolog\u00eda de la longevidad<\/li>\n \t<li>Investigaci\u00f3n sobre la din\u00e1mica de fosforilaci\u00f3n de S6K1 y 4E-BP1 y la regulaci\u00f3n de la s\u00edntesis de prote\u00ednas<\/li>\n \t<li>Biolog\u00eda del c\u00e1ncer \u2014 desregulaci\u00f3n de la v\u00eda mTOR y estudios de mecanismos antiproliferativos<\/li>\n \t<li>Interacci\u00f3n de la prote\u00edna FKBP12 y farmacolog\u00eda comparativa de an\u00e1logos de rapamicina (rapalogs)<\/li>\n<\/ul>\n<h3 style=\"color: #1a7a6e;margin-top: 20px\">Especificaciones t\u00e9cnicas<\/h3>\n<table style=\"width: 100%;border-collapse: collapse;margin: 10px 0\">\n<tbody>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Compuesto<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Sirolimus (Rapamicina)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">F\u00f3rmula molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">C\u2085\u2081H\u2087\u2089NO\u2081\u2083<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Peso molecular<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">~914.17 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">N\u00famero CAS<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">53123-88-9<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Mecanismo<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Inhibidor alost\u00e9rico de mTORC1 (dependiente de FKBP12)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Pureza<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">\u226598% (especificaci\u00f3n del proveedor)<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Forma<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Tableta oral (5 mg)<\/td>\n<\/tr>\n<tr style=\"background: #fff\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Cantidad<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">10 tabletas por envase<\/td>\n<\/tr>\n<tr style=\"background: #eaf5f3\">\n<td style=\"padding: 6px 10px;font-weight: bold;width: 35%;border: 1px solid #ccc\">Almacenamiento<\/td>\n<td style=\"padding: 6px 10px;border: 1px solid #ccc\">Lugar fresco y seco, alejado del calor, la humedad y la luz directa<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"background: #fff8e7;border-top: 2px solid #d4a017;border-bottom: 2px solid #d4a017;padding: 10px;margin-top: 20px\"><strong>SOLO PARA USO EN INVESTIGACI\u00d3N.<\/strong> No est\u00e1 destinado al consumo humano ni veterinario, ni al diagn\u00f3stico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n m\u00e9dica. Este producto no ha sido evaluado por la FDA ni por ning\u00fan organismo regulador. Debe ser manipulado por personal de investigaci\u00f3n calificado en un entorno de laboratorio que cumpla con la normativa vigente. Estas declaraciones no han sido evaluadas por la Administraci\u00f3n de Alimentos y Medicamentos de los Estados Unidos.<\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo est\u00e1s seguro de qu\u00e9 compuestos se adaptan a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Centro de Investigaci\u00f3n \u2192<\/a><\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>Sirolimus (rapamycin), un inhibidor de mTORC1 utilizado como compuesto de referencia en investigaci\u00f3n sobre la detecci\u00f3n de nutrientes, la autofagia y el envejecimiento. Suministrado exclusivamente para investigaci\u00f3n en laboratorio y fines de identificaci\u00f3n.<\/p>","protected":false},"featured_media":799,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"","ptw_coa_url":"","ptw_science_overview":"","ptw_science_research":"","ptw_science_stack":"","_ptw_batch_number":""},"product_brand":[35],"product_cat":[521],"product_tag":[48,451,450,430,449],"class_list":["post-705","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-mitochondrial-longevity","product_tag-longevity-2","product_tag-mtor","product_tag-rapamycin","product_tag-research","product_tag-tablet","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=705"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/799"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=705"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=705"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=705"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}