{"id":83,"date":"2025-01-29T18:07:27","date_gmt":"2025-01-30T00:07:27","guid":{"rendered":"https:\/\/portaltowellness.net\/?post_type=product&#038;p=83"},"modified":"2026-10-09T09:23:22","modified_gmt":"2026-10-09T14:23:22","slug":"ipamorelin-10mg","status":"publish","type":"product","link":"https:\/\/portaltowellness.net\/es\/shop\/ipamorelin-10mg\/","title":{"rendered":"Ipamorelin \u2013 10mg\/vial (Solo para uso en investigaci\u00f3n)"},"content":{"rendered":"<div class=\"notranslate\" translate=\"no\" data-wg-notranslate data-no-translation=\"\"><h2>Descripci\u00f3n general<\/h2>\n<p><!-- wp:html --><\/p>\n<p><style>.ptw-product-research-link{background:#f6f3ec;border:1px solid #e0d9c8;border-left:4px solid #8a7a4d;border-radius:8px;padding:14px 18px;margin:16px 0 20px;font-size:15px;}.ptw-product-research-link__label{display:block;font-size:11px;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:#8a7a4d;margin-bottom:6px;}.ptw-product-research-link__link{display:block;color:#1a2b4c;font-weight:600;text-decoration:underline;margin-top:3px;}<\/style>\n<\/p>\n<p><!-- \/wp:html --><br \/><!-- wp:html --><\/p>\n<div class=\"ptw-product-research-link\"><span class=\"ptw-product-research-link__label\">Respaldado por la investigaci\u00f3n<\/span><a class=\"ptw-product-research-link__link\" href=\"https:\/\/portaltowellness.net\/research\/glp1-adjunct-peptide-research-guide\/\">Leer: Compuestos incret\u00ednicos y del eje de la hormona de crecimiento en la literatura \u2192<\/a><\/div>\n<p><!-- \/wp:html --><\/p>\n<p>La ipamorelina es un pentap\u00e9ptido sint\u00e9tico bien caracterizado, secretagogo de hormona de crecimiento (GHS) y agonista selectivo del GHSR-1a (receptor de ghrelina). La ipamorelina se distingue en la literatura farmacol\u00f3gica publicada por su agonismo selectivo del GHSR-1a sin coestimulaci\u00f3n significativa de ACTH, cortisol o prolactina \u2014 un perfil de selectividad que la convierte en un compuesto de referencia ampliamente utilizado en investigaciones que a\u00edslan la se\u00f1alizaci\u00f3n espec\u00edfica de GH de los efectos neuroendocrinos m\u00e1s amplios.<\/p>\n<h2>Qu\u00e9 es<\/h2>\n<p>La ipamorelina es un pentap\u00e9ptido sint\u00e9tico (5 amino\u00e1cidos) secretagogo de GH con la secuencia Aib-His-D-2Nal-D-Phe-Lys-NH\u2082 y un peso molecular de aproximadamente 711 Da. Es un agonista selectivo del receptor secretagogo de hormona de crecimiento tipo 1a (GHSR-1a), el receptor end\u00f3geno de la ghrelina. La caracterizaci\u00f3n farmacol\u00f3gica publicada distingui\u00f3 a la ipamorelina del GHRP-2, GHRP-6 y hexarelina por su falta de estimulaci\u00f3n significativa de c\u00e9lulas cortic\u00f3tropas o de c\u00e9lulas productoras de prolactina en sistemas de cultivo de c\u00e9lulas hipofisarias.<\/p>\n<h2>Investigaci\u00f3n destacada<\/h2>\n<p>La historia de investigaci\u00f3n farmacol\u00f3gica de la ipamorelina est\u00e1 fundamentada en estudios fundacionales de uni\u00f3n a radioligandos y ensayos funcionales que establecen su afinidad por GHSR-1a, su eficacia intr\u00ednseca y su perfil de selectividad. Los estudios publicados en cultivo de c\u00e9lulas hipofisarias documentaron la liberaci\u00f3n de GH dependiente de la concentraci\u00f3n sin cosecreci\u00f3n significativa de cortisol o ACTH \u2014 el hallazgo clave de selectividad que diferenci\u00f3 a la ipamorelina de los secretagogos de GH anteriores. La investigaci\u00f3n sobre farmacolog\u00eda de pulsos de GH in vivo en modelos de roedores y porcinos ha documentado relaciones dosis-respuesta, tiempos de pico plasm\u00e1tico de GH y par\u00e1metros de amplitud del pulso de GH tanto en dise\u00f1os de administraci\u00f3n \u00fanica como m\u00faltiple. La combinaci\u00f3n ipamorelina\/CJC-1295 (sin DAC) ha sido documentada como un modelo para estudiar la amplificaci\u00f3n sin\u00e9rgica del pulso de GH mediante la coestimulaci\u00f3n simult\u00e1nea del receptor de GHRH y el receptor de ghrelina. La investigaci\u00f3n sobre la respuesta del eje IGF-1 tras la administraci\u00f3n de ipamorelina ha sido publicada en m\u00faltiples contextos de modelos animales.<\/p>\n<h2>Principales aplicaciones de investigaci\u00f3n<\/h2>\n<ul>\n<li>Caracterizaci\u00f3n de uni\u00f3n al receptor GHSR-1a, afinidad y selectividad<\/li>\n<li>Farmacolog\u00eda del secretagogo selectivo de GH \u2014 aislado de los factores de confusi\u00f3n de ACTH\/cortisol<\/li>\n<li>Modelado de dosis-respuesta de la liberaci\u00f3n puls\u00e1til de GH en modelos de roedores y porcinos<\/li>\n<li>Investigaci\u00f3n de combinaci\u00f3n de secretagogos de GH (estudios de sinergia ipamorelina + CJC-1295)<\/li>\n<li>Investigaci\u00f3n comparativa de agonistas del GHSR-1a frente a GHRP-2, GHRP-6, hexarelina<\/li>\n<li>Medici\u00f3n de la respuesta descendente del eje IGF-1 en modelos animales<\/li>\n<li>Caracterizaci\u00f3n farmacocin\u00e9tica del secretagogo de GH<\/li>\n<li>Estudios de selectividad de c\u00e9lulas somat\u00f3tropas hipofisarias e internalizaci\u00f3n del receptor<\/li>\n<\/ul>\n<p><em>Solo para uso en investigaci\u00f3n de laboratorio. No est\u00e1 destinado a uso humano o veterinario, ni al diagn\u00f3stico m\u00e9dico, tratamiento o prevenci\u00f3n de ninguna enfermedad o condici\u00f3n. Este producto no ha sido evaluado por la FDA ni por ning\u00fan organismo regulador. Debe ser manejado por personal de investigaci\u00f3n calificado en un entorno de laboratorio que cumpla con la normativa aplicable.<\/em><\/p>\n<p style=\"margin-top: 20px;padding: 14px 18px;background: #f0f6fa;border-left: 4px solid #c9a44d;border-radius: 0 4px 4px 0;font-size: 0.9rem;line-height: 1.5\">\u00bfNo est\u00e1s seguro de qu\u00e9 compuestos se adaptan a tu investigaci\u00f3n? <a style=\"color: #0c2b3a;font-weight: bold;text-decoration: none\" href=\"https:\/\/portaltowellness.net\/research\/\">Explora el Centro de Investigaci\u00f3n \u2192<\/a><\/p>\n<p><!-- PTW-RESEARCH-LINKS --><\/p>\n<h3>Investigaci\u00f3n relacionada (educativa)<\/h3>\n<ul>\n<li><a href=\"https:\/\/portaltowellness.net\/research\/sleep-repair-energy-one-system\/\">V\u00edas superpuestas en biolog\u00eda circadiana, de reparaci\u00f3n y mitocondrial<\/a><\/li>\n<\/ul><\/div>","protected":false},"excerpt":{"rendered":"<p>P\u00e9ptido secretagogo selectivo de GH estudiado en investigaci\u00f3n sobre liberaci\u00f3n de GH, sue\u00f1o y recuperaci\u00f3n. Solo para uso en investigaci\u00f3n.<\/p>","protected":false},"featured_media":1119,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ptw_protocol_fit":"","ptw_why_this":"","ptw_coa_url":"","ptw_science_overview":"","ptw_science_research":"","ptw_science_stack":"","_ptw_batch_number":""},"product_brand":[35],"product_cat":[550,510,520,521],"product_tag":[489,429,430],"class_list":["post-83","product","type-product","status-publish","has-post-thumbnail","product_brand-portal-to-wellness","product_cat-hormone-circadian","product_cat-best-sellers","product_cat-metabolic-research","product_cat-mitochondrial-longevity","product_tag-ghrp","product_tag-injectable","product_tag-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product\/83","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/comments?post=83"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media\/1119"}],"wp:attachment":[{"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/media?parent=83"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_brand?post=83"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_cat?post=83"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/portaltowellness.net\/es\/wp-json\/wp\/v2\/product_tag?post=83"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}