# Ageing-Biology Research Index **Research Use Only.** All compounds are for laboratory and research purposes only. Not for human consumption. Portal to Wellness complies with all applicable regulations. Ageing-Biology Research Index # Ageing, Studied *Mechanism by Mechanism.* GHK-Cu, Epithalon and NAD+ are studied against different hallmarks of ageing — cellular renewal, collagen synthesis and telomere biology. This guide summarises what the published research reports for each. [Shop Mitochondrial & Longevity →](https://portaltowellness.net/product-category/mitochondrial-longevity/) [View the Ageing-Biology Research Set](https://portaltowellness.net/shop/longevity-essentials-bundle/) **15+** Longevity Compounds **GHK-Cu** Collagen & Elastin Signaling **Epithalon** Telomere Extension Research A Long Research Record ## Decades of published research. GHK-Cu has 40+ years of research behind it. Epithalon was studied for decades in Russia before Western researchers took notice. NAD+ research spans multiple Nobel Prize-adjacent discoveries. These aren’t new — they’ve just been ignored by the cosmetic industry until recently. #### GHK-Cu — Copper Peptide Research Discovered in 1973, GHK-Cu upregulates over 70 genes involved in collagen, elastin, and glycosaminoglycan synthesis. It also downregulates genes associated with inflammation and aggressive tissue destruction. #### Epithalon — Telomere Research at the Cellular Level A tetrapeptide derived from the pineal gland, Epithalon is studied for its ability to activate telomerase — the enzyme that maintains telomere length. Shorter telomeres correlate with biological aging. The published work is largely in cell cultures and animal models. ✨ ### Research at the level of mechanism The compounds on this page are studied against specific biological mechanisms — collagen gene expression, telomere length, mitochondrial energy and inflammatory signalling — not against visible outcomes. Research compounds — not cosmetic claims What These Compounds Are Studied For ## Cellular mechanisms. 🧴 #### Collagen & Extracellular Matrix GHK-Cu and BPC-157 are studied for their effects on collagen I, III and elastin gene expression in preclinical models. 🔬 #### Telomere Biology Epithalon is studied for telomerase activation, mainly in cell-culture and animal work. ⚡ #### Cellular Energy & NAD+ Published measurements report NAD+ declining with age. Research examines its role in DNA repair, sirtuin activity and mitochondrial function. 💎 #### Oxidative Stress Glutathione, the body’s primary endogenous antioxidant, is studied for its role in oxidative-stress pathways. Featured Compounds ## Longevity Research Compounds [View All Longevity →](https://portaltowellness.net/product-category/mitochondrial-longevity/) Flagship Product Copper Peptide Complex Collagen · Tissue Signalling GLOW-70 — GHK-Cu + TB-500 + BPC-157 (50+10+10mg) A single vial combining GHK-Cu (50mg), TB-500 (10mg) and BPC-157 (10mg). GHK-Cu is studied for collagen and elastin gene expression, TB-500 for cell migration, and BPC-157 for angiogenesis, in preclinical tissue models. $112.00 [View →](https://portaltowellness.net/shop/glow-70/) Longevity Cornerstone Telomere Peptide Telomerase · Pineal Epithalon — 40mg/vial A tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland protein Epithalamin. Research published over three decades, much of it by Russian groups, reports telomerase activation and telomere elongation in cell cultures, and antioxidant and circadian effects in animal models. $119.00 [View →](https://portaltowellness.net/shop/epithalon/) Cellular Coenzyme Energy · DNA Repair · Sirtuins NAD+ — Most Popular (500mg/vial) NAD+ is the essential coenzyme of cellular metabolism, sirtuin activation, and DNA damage repair. Published measurements report that NAD+ levels decline with age, and research examines its roles in energy metabolism, cellular stress responses and circadian regulation. From $65.00 [View →](https://portaltowellness.net/shop/nad-plus/) Master Antioxidant Antioxidant · Redox Glutathione — 1500mg/vial The body’s primary endogenous antioxidant — a tripeptide (Glu-Cys-Gly) produced in every cell. Research describes its roles in neutralising reactive oxygen species, phase II conjugation and protecting DNA from oxidative damage. $49.00 [View →](https://portaltowellness.net/shop/glutathione/) Immune & Longevity Peptide Thymus · Immune · Aging Thymalin — 10mg/vial A peptide isolated from the thymus gland — the organ responsible for T-cell maturation that involutes dramatically with age. Thymalin research, much of it by Russian groups, examines thymic function and immune markers in ageing. $49.50 [View →](https://portaltowellness.net/shop/thymalin/) Mitochondrial Peptide AMPK · Metabolism · Aging MOTS-c — 40mg/vial A mitochondria-derived peptide that translocates to the nucleus under stress to regulate metabolic homeostasis. In animal studies MOTS-c activates AMPK, and it has been studied for effects on insulin sensitivity and markers of ageing. It represents a new class of mitokine that bridges metabolic health and longevity biology. $149.00 [View →](https://portaltowellness.net/shop/mots-c-40mg-vial/) Curated Kit ## The Ageing-Biology Research Set Four compounds studied against four different hallmarks of ageing — Epithalon for telomere biology, Thymalin for thymic function, NAD+ for co-enzyme supply and SS-31 for mitochondrial membrane structure. Priced 20% below buying the four separately. Epithalon Telomere biology + Thymalin Thymic function + NAD+ Co-enzyme supply + SS-31 Mitochondrial membrane [View the Ageing-Biology Research Set — Save 20% →](https://portaltowellness.net/shop/longevity-essentials-bundle/) The Science ## Three ageing mechanisms, as studied. Aging isn’t one process — it’s a convergence of cellular pathways. The compounds below are grouped by the pathway they are studied against. Mechanism 01 #### Collagen & Extracellular Matrix Degradation With age, collagen production declines and matrix metalloproteinases (MMPs) increase — degrading the structural proteins that maintain tissue structure. GHK-Cu is studied for its effects on MMP and collagen gene expression. → GHK-Cu (GLOW-70) · BPC-157 · TB-500 Mechanism 02 #### Telomere Shortening & Cellular Senescence Each cell division shortens telomeres — the protective caps on chromosomes. When telomeres become critically short, cells enter senescence, secreting inflammatory signals (SASP) that accelerate tissue aging. Epithalon is studied for telomerase activation. → Epithalon · Thymalin · Sirolimus (mTOR) Mechanism 03 #### NAD+ Decline & Mitochondrial Dysfunction NAD+ is required for sirtuin deacetylase activity — the “longevity proteins” that regulate DNA repair, gene expression, and metabolic health. As NAD+ declines, mitochondria produce less ATP and more reactive oxygen species, driving systemic aging from the cellular energy level up. → NAD+ · MOTS-c · SS-31 · Glutathione ## Not sure where to begin? The Research Hub sets out the published research on every compound we carry. [Browse the Research Hub →](https://portaltowellness.net/research/) **Portal to Wellness** · [portaltowellness.net](https://portaltowellness.net) Research and laboratory use only. Not for human consumption. These compounds are not intended to diagnose, treat, cure, or prevent any disease. Statements about research outcomes are based on published scientific literature and do not represent guarantees of individual results. Consult a licensed healthcare provider before beginning any research. © 2026 Portal to Wellness · [Privacy Policy](https://portaltowellness.net/privacy-policy/) · [Terms of Service](https://portaltowellness.net/terms-of-service/) --- Source: https://portaltowellness.net/longevity-compound-index/ Research use only. Terms: https://portaltowellness.net/research-use-only/