# Longevity and Ageing Research Compounds

## Longevity and Ageing Research Compounds

This page indexes catalogue compounds that appear in the geroscience and cellular-ageing literature. It describes mechanism and evidence stage only. It is not guidance for use, and no combination, sequence or quantity is recommended here.

### Mitochondrial and NAD Metabolism

- **[NAD⁺](https://portaltowellness.net/shop/mitochondrial-energy-bundle/)** — a coenzyme required for redox reactions and consumed by sirtuin and PARP enzymes. Declining tissue NAD⁺ with age is one of the more consistently reported findings in the ageing literature; the mechanisms proposed for that decline, including CD38 activity and NAMPT expression, are reviewed in [NAD decline: CD38 and NAMPT](https://portaltowellness.net/research/nad-decline-cd38-nampt-research/) .
- **[MOTS-c](https://portaltowellness.net/shop/mots-c-40mg-vial/)** — a mitochondrial-derived peptide studied in AMPK signalling models. Background: [MOTS-c research](https://portaltowellness.net/research/mots-c-mitochondrial-peptide-research/) .

SS-31, MOTS-c and NAD⁺ are frequently discussed together in the 2024–2026 mitochondrial literature despite acting through different mechanisms; the differences are set out in the [mitochondrial compound comparison](https://portaltowellness.net/research/mitochondrial-peptide-comparison-ss31-mots-c-nad/) .

### Structural and Extracellular Matrix Research

- **GHK-Cu** — a copper-binding tripeptide studied in fibroblast and extracellular-matrix models, including collagen gene expression. Background: [peptides and collagen production research](https://portaltowellness.net/research/peptides-collagen-production-research/) .

### How This Literature Should Be Read

Most compounds discussed under the longevity heading have been characterised in cell culture and animal models. Biomarker movement in those models is not the same thing as a demonstrated effect on lifespan or healthspan in humans, a distinction covered in [biomarkers versus clinical outcomes](https://portaltowellness.net/research/biomarkers-vs-clinical-outcomes-research/) and in [how longevity research is structured](https://portaltowellness.net/research/longevity-research-101-compound-classes-by-biological-system/) . No compound listed here has an approved status for any age-related indication.

**Research use only.** All compounds referenced on this page are supplied for laboratory research use only. They are not drugs, foods or cosmetics, and are not for human or veterinary use. Nothing on this page is a therapeutic claim, and no diagnosis, treatment, cure or prevention of any condition is stated or implied.

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Source: https://portaltowellness.net/longevity-kit/
Research use only. Terms: https://portaltowellness.net/research-use-only/