# 5-Amino-1MQ – 50mg × 25pcs (Research Use Only)

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### Overview

5-amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. By inhibiting NNMT, 5-amino-1MQ research has examined effects on cellular SAM availability, one-carbon metabolism, NAD+ precursor cycling, and adipocyte biology. Published preclinical research has examined its effects on adipogenesis, adipocyte size, lipid accumulation, and energy expenditure in cell culture and rodent models, making it a research tool for metabolic and adipose tissue biology investigations.

### What It Is

5-amino-1MQ is a charged small-molecule compound (quaternary ammonium salt) with the molecular formula C₁₀H₁₁N₂⁺ (as the methylated quinolinium), MW approximately 159.21 Da (cation). It acts as a competitive inhibitor of NNMT by occupying the nicotinamide binding site, reducing the enzyme’s ability to consume SAM and produce 1-methylnicotinamide (1-MNA). This preserves SAM pools for other methylation reactions and shifts NAD+ precursor dynamics. CAS number: 1392274-18-8.

### Key Research Applications

- NNMT enzyme inhibition and one-carbon methyl group transfer pathway research
- SAM availability, methylation capacity, and epigenetic regulation studies
- Adipogenesis, adipocyte lipid accumulation, and fat cell biology research
- NAD+ biosynthesis, salvage pathway flux, and nicotinamide metabolism studies
- White adipose tissue browning and thermogenesis marker research
- Obesity and metabolic syndrome preclinical modeling studies
- NNMT expression in aging, cancer, and metabolic disease contexts
- Comparative NNMT inhibitor pharmacology and selectivity characterization

### Technical Specifications

| Compound | 5-Amino-1-methylquinolinium (5-amino-1MQ) |
| --- | --- |
| Molecular Weight | ~159.21 Da (cation) |
| CAS Number | 1392274-18-8 |
| Mechanism | NNMT (Nicotinamide N-Methyltransferase) Inhibitor |
| Purity | ≥98% (supplier specification) |
| Form | Oral capsule (50mg) |
| Quantity | 25 capsules per bottle |
| Storage | Room temperature, away from moisture and light |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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