# 5-Amino-1MQ – 50mg/vial (Research Use Only)

## 5-Amino-1MQ – 50mg/vial

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a cell-permeable small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), with a molecular weight of approximately 174 Da. This vial contains 50mg of research-grade 5-Amino-1MQ supplied as a lyophilized powder for preclinical research applications. NNMT catalyzes the N-methylation of nicotinamide using S-adenosyl methionine (SAM) as the methyl donor.

### Research Background

Investigators have studied 5-Amino-1MQ as a selective pharmacological tool for probing NNMT enzyme function. Published in vitro research has examined NNMT inhibitor effects on NAD+ precursor availability, methylation pathway flux, and adipocyte differentiation in cell culture models. In vivo research using injectable formats has examined NNMT inhibition in rodent models, with investigators measuring adipose tissue mass, metabolic substrate utilization, and gene expression markers relevant to lipid metabolism. Published pharmacokinetic studies have examined the bioavailability and tissue distribution of 5-Amino-1MQ in animal models.

### Technical Specifications

| **Compound Class** | Small molecule NNMT inhibitor |
| --- | --- |
| **Molecular Weight** | ~174 Da |
| **Purity** | ≥98% (supplier specification) |
| **Form** | Lyophilized powder (injectable-grade formulation) |
| **Vial Size** | 50mg |
| **Storage** | −4 °F long-term |

*For research use only. Not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition.*

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