# ARA-290 – 10mg/vial (Research Use Only)

### Overview

ARA-290 (also known as Cibinetide) is a synthetic 11-amino acid peptide based on the Helix B region of erythropoietin (EPO) — specifically designed to activate the innate repair receptor (IRR, composed of the EPO receptor homodimer or the tissue-protective heteroreceptor with CD131/βc) while avoiding the hematopoietic erythropoietin receptor (EPOR homodimer). This molecular engineering approach has allowed researchers to study EPO’s non-hematopoietic tissue-protective effects — in neurological, metabolic, and inflammatory models — independently of its red blood cell-stimulating activity, providing an important mechanistic tool for dissecting EPO receptor biology.

### What It Is

ARA-290 is an 11-amino acid linear peptide derived from the Helix B surface of human EPO, with MW approximately 1,264 Da, CAS number 1234356-69-4. Its sequence corresponds to EPO residues 58-82 (Helix B) and lacks the EPOR homodimer binding epitopes required for erythropoiesis. It preferentially engages the innate repair receptor complex (heterodimer with CD131/βc) at peripheral and central tissue sites, activating cytoprotective signaling cascades including PI3K/Akt and NF-κB without stimulating hematopoiesis.

### Key Research Applications

- Innate repair receptor (IRR) activation and EPO tissue-protective signaling research
- Non-hematopoietic EPO receptor biology — PI3K/Akt and anti-apoptotic pathway studies
- Neuropathic pain research — small fiber neuropathy and corneal nerve fiber density studies
- Peripheral neuropathy preclinical modeling and nerve regeneration research
- Inflammatory cytokine suppression and tissue cytoprotection mechanism studies
- Diabetic complications modeling — peripheral neuropathy and retinal research
- EPO receptor homodimer vs. heterodimer (IRR) selectivity pharmacology research
- Sarcoidosis, inflammatory neuropathy, and systemic inflammatory disease modeling

### Technical Specifications

| Amino Acids | 11 (Helix B EPO-derived) |
| --- | --- |
| Molecular Weight | ~1,264 Da |
| CAS Number | 1234356-69-4 |
| Also Known As | Cibinetide; Helix B surface peptide (HBSP) |
| Mechanism | Innate Repair Receptor (IRR) Agonist — non-hematopoietic |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 10mg |
| Storage | −4 °F long-term |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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### Related research (educational)

- [Recovery & Repair Research Compounds: A Complete Guide](https://portaltowellness.net/research/recovery-repair-research-compounds-guide/)

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