# DSIP – 15mg/vial (Research Use Only)

### Overview

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring 9-amino acid neuropeptide originally isolated by Marcel Monnier from thalamic perfusate capable of inducing slow-wave (delta) sleep in rabbits. Since its discovery and characterization in the 1970s, DSIP has accumulated a diverse published research base spanning sleep biology, neuroendocrine regulation, stress response modulation, and antioxidant mechanism research. Its interactions with multiple neurotransmitter systems — including opioidergic, serotonergic, and glutamatergic pathways — alongside published data on LH, somatostatin, and ACTH modulation have made DSIP an unusually multifaceted neuropeptide research subject.

### What It Is

DSIP (delta sleep-inducing peptide) is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, MW approximately 849 Da, CAS number 62568-57-4. Despite its small size, DSIP has been reported in published research to cross the blood-brain barrier and is detectable in peripheral blood, cerebrospinal fluid, and multiple peripheral organs. Its published neuroendocrine effects include modulation of LH release, ACTH secretion, somatostatin secretion, and basal corticosterone, with additional published work on antioxidant enzyme activity and stress-protective properties in animal models.

### Key Research Applications

- Sleep architecture, slow-wave (delta) sleep induction, and EEG endpoint research
- Hypothalamic-pituitary axis modulation — LH, ACTH, and somatostatin regulation studies
- Opioidergic, serotonergic, and glutamatergic neuropeptide interaction research
- Stress response attenuation and HPA axis modulation in animal models
- Antioxidant enzyme (SOD, catalase) activity and oxidative stress biomarker studies
- BBB penetration and neuropeptide CNS access research
- Circadian biology and sleep-wake cycle regulatory peptide research
- Comparative sleep peptide pharmacology vs. other endogenous sleep modulators

### Technical Specifications

| Amino Acids | 9 (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) |
| --- | --- |
| Molecular Weight | ~849 Da |
| CAS Number | 62568-57-4 |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 15mg |
| Storage | −4 °F long-term |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

Not sure which compounds fit your research? [Browse the Research Hub →](https://portaltowellness.net/research/)

### Related research (educational)

- [DSIP & Epithalon: What the Research Says About Sleep and Circadian Peptides](https://portaltowellness.net/research/dsip-epithalon-what-the-research-says-about-sleep-and-circadian-peptides/)
- [Overlapping Pathways in Circadian, Repair and Mitochondrial Biology](https://portaltowellness.net/research/sleep-repair-energy-one-system/)

Regulatory Status Note

On July 23–24, 2026, FDA’s Pharmacy Compounding Advisory Committee reviewed whether BPC-157, TB-500, KPV, MOTS-c, Semax, Epitalon, and emideltide (DSIP) should be added to the 503A Bulks List for pharmacy compounding. The committee voted to recommend six of the seven; emideltide (DSIP) was **not** recommended. FDA’s own briefing documents had recommended against all seven.

A committee vote is a recommendation only. It does not constitute FDA approval, does not establish safety or effectiveness, and does not change the status of this product, which is sold strictly for research use. FDA must complete formal rulemaking before any substance is added to the list. [Source: FDA Advisory Committee Calendar](https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026) . Last reviewed: August 17, 2026.

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Source: https://portaltowellness.net/shop/dsip/
Research use only. Terms: https://portaltowellness.net/research-use-only/