# Humanin – 10mg/vial (Research Use Only)

### Overview

Humanin is a 21-amino acid mitochondria-derived peptide (MDP) encoded within the 16S ribosomal RNA gene of the mitochondrial genome. First identified in research examining neuronal survival in Alzheimer’s disease models, humanin has accumulated a published literature spanning neuroprotection, metabolic biology, cardiovascular research, and longevity science. Its discovery opened a research frontier examining how mitochondria communicate with the nucleus, other organelles, and distant tissues through secreted peptide signals.

### What It Is

Humanin (HN) is a 21-amino acid peptide encoded within the mitochondrial 16S rRNA gene. MW approximately 2,586 Da, CAS number 330936-46-4. It signals through a receptor complex involving CNTFR/WSX-1/gp130 and also directly interacts with pro-apoptotic proteins including IGFBP-3, Bax, and tBid intracellularly. Humanin is secreted into the bloodstream and detected in human plasma, with levels declining with age.

### Key Research Applications

- Mitochondria-derived peptide (MDP) signaling and mitochondrial-nuclear communication research
- Neuroprotection and amyloid-beta toxicity inhibition studies in Alzheimer’s preclinical models
- Anti-apoptotic mechanism research — Bax, IGFBP-3, and tBid interaction studies
- gp130/CNTFR/WSX-1 receptor complex activation and STAT3 pathway research
- Mitochondrial function, bioenergetics, and aging biology studies
- Insulin sensitivity, glucose metabolism, and pancreatic beta-cell survival research
- Cardiovascular protection — cardiac apoptosis and ischemia-reperfusion injury modeling
- Age-related MDP decline and longevity marker correlation studies

### Technical Specifications

| Amino Acids | 21 |
| --- | --- |
| Molecular Weight | ~2,586 Da |
| CAS Number | 330936-46-4 |
| Origin | Mitochondrial 16S rRNA gene-encoded peptide |
| Mechanism | gp130/CNTFR/WSX-1 agonism; anti-apoptotic interactions |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 10mg |
| Storage | −4 °F long-term |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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### Related research (educational)

- [Mitochondrial Peptide Comparison: SS-31, MOTS-c, and NAD+](https://portaltowellness.net/research/mitochondrial-peptide-comparison-ss31-mots-c-nad/)
- [Overlapping Pathways in Circadian, Repair and Mitochondrial Biology](https://portaltowellness.net/research/sleep-repair-energy-one-system/)

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Research use only. Terms: https://portaltowellness.net/research-use-only/