# IGF-1 LR3 – 1mg/vial (Research Use Only)

Backed by the Research [Read: How Incretin and Growth-Hormone-Axis Compounds in the Literature →](https://portaltowellness.net/research/glp1-adjunct-peptide-research-guide/)

### Overview

IGF-1 LR3 (Long-Arginine-3 IGF-1) is a synthetic long-acting analogue of human insulin-like growth factor 1 (IGF-1) engineered for research applications requiring extended receptor activation and reduced IGFBP binding. By substituting glutamate at position 3 with arginine and prepending a 13-amino acid extension peptide at the N-terminus, IGF-1 LR3 achieves markedly reduced binding to IGF-binding proteins (IGFBPs) and a correspondingly extended plasma half-life compared to native IGF-1 — making it the preferred research tool for sustained IGF-1 receptor pathway studies.

### What It Is

IGF-1 LR3 is an 83-amino acid synthetic analogue of human IGF-1, incorporating a 13-residue N-terminal extension and a Glu³→Arg substitution. Its molecular weight is approximately 9,117 Da. It has ~2–3% of the IGFBP binding affinity of native IGF-1, resulting in an estimated half-life of 20–30 hours in vivo versus the ~12-minute half-life of native IGF-1. CAS number: 946870-92-4.

### Key Research Applications

- IGF-1 receptor (IGF-1R) activation, downstream PI3K/Akt/mTOR signaling research
- Myoblast proliferation, differentiation, and skeletal muscle tissue culture studies
- Satellite cell activation and muscle regeneration pathway research
- Bone anabolic signaling, osteoblast function, and skeletal growth research
- Long-acting IGF-1 analogue pharmacokinetics and IGFBP interaction studies
- GH/IGF-1 axis dissociation studies — GH-independent IGF-1R activation research
- Neuroprotection, neuronal survival, and CNS IGF-1 receptor biology
- Comparative pharmacology vs. native IGF-1 and des(1-3) IGF-1 fragments

### Technical Specifications

| Amino Acids | 83 |
| --- | --- |
| Molecular Weight | ~9,117 Da |
| CAS Number | 946870-92-4 |
| Mechanism | IGF-1 Receptor Agonist (Extended Half-Life) |
| IGFBP Binding | ~2–3% of native IGF-1 |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 1mg |
| Storage | −4 °F long-term |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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