# MT-II – 10mg/vial (Research Use Only)

## Overview

Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) with broad, non-selective melanocortin receptor agonist activity across MC1R through MC5R subtypes. Originally developed at the University of Arizona as part of a research program to identify sunless tanning agents, Melanotan II’s research profile has expanded across melanocortin receptor pharmacology, central nervous system behavioral research, metabolic biology, and cardiovascular studies. Its structural parent, PT-141 (Bremelanotide), was derived from MT-II with modifications to improve tolerability, providing a natural comparative pharmacology pairing for melanocortin receptor research.

## What It Is

Melanotan II is a cyclic lactam heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, molecular formula C₅₀H₆₉N₁₅O₉, MW approximately 1,024.18 Da, CAS number 121062-08-6. Its broad melanocortin receptor activation profile (MC1R-MC5R) distinguishes it from PT-141 (which is more selective for MC3R/MC4R) and from natural α-MSH. The cyclization and Nle substitution provide metabolic stability exceeding that of linear α-MSH analogues.

## Key Research Applications

- Broad-spectrum melanocortin receptor (MC1R–MC5R) pharmacology and selectivity research
- Melanocyte pigmentation, MC1R activation, and melanogenesis biology studies
- MC3R and MC4R CNS pathway research — appetite, arousal, and reward circuit studies
- Comparative melanocortin receptor agonist pharmacology vs. PT-141 (bremelanotide) and α-MSH
- Cardiovascular research — MC3R/MC4R mediated blood pressure and cardiac effects
- Anti-inflammatory melanocortin pathway studies via peripheral MC receptor activation
- Cyclic α-MSH analogue structure-activity relationship (SAR) research
- Peripheral MC4R/MC5R tissue receptor biology studies in smooth muscle preparations

## Technical Specifications

| **Structure** | Cyclic lactam heptapeptide |
| --- | --- |
| **Molecular Formula** | C₅₀H₆₉N₁₅O₉ |
| **Molecular Weight** | ~1,024.18 Da |
| **CAS Number** | 121062-08-6 |
| **Receptor Profile** | Broad MC1R–MC5R agonist |
| **Purity** | ≥98% (supplier specification) |
| **Form** | Lyophilized powder |
| **Vial Size** | 10mg |

*For laboratory research use only. Not intended for human or veterinary use, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting.*

Not sure which compounds fit your research? [Browse the Research Hub →](https://portaltowellness.net/research/)

---

Source: https://portaltowellness.net/shop/mt-ii/
Research use only. Terms: https://portaltowellness.net/research-use-only/