# SR9009 – 10mg × 100 tablets (Research Use Only)

### Overview

SR9009 is a synthetic small-molecule agonist of Rev-Erb alpha (NR1D1) and Rev-Erb beta (NR1D2) — nuclear receptors that function as core components of the circadian clock machinery and transcriptional regulators of metabolic gene networks. As the pharmacological tool that enabled definitive characterization of Rev-Erb’s role in metabolic programming, circadian rhythm regulation, and mitochondrial biogenesis, SR9009 has generated significant published research interest. Published studies have examined SR9009’s effects on lipid and glucose metabolism, mitochondrial content, and circadian behavior in multiple rodent model systems.

### What It Is

SR9009 is a synthetic benzimidazole thiopropylamine with molecular formula C₂₃H₂₆ClN₃O₃S, MW ~480.0 Da, CAS number 1379686-30-2. It acts as a direct ligand for Rev-Erb alpha (NR1D1) and Rev-Erb beta (NR1D2) nuclear receptor ligand-binding domains, displacing the co-repressor NCoR/HDAC3 complex from these receptors and altering transcriptional activity of Rev-Erb target genes including BMAL1, CLOCK, and metabolic regulators including PPAR-gamma, SREBP-1c, and PGC-1alpha.

### Key Research Applications

- Rev-Erb alpha/beta (NR1D1/NR1D2) receptor agonism and circadian clock transcription research
- BMAL1, CLOCK, and circadian gene network regulation studies
- Lipid metabolism, cholesterol biosynthesis, and bile acid pathway research
- Glucose homeostasis, hepatic gluconeogenesis, and glycogen metabolism studies
- Mitochondrial biogenesis, oxidative metabolism, and exercise capacity marker research
- Adipogenesis, fat cell differentiation, and adipokine regulation studies
- Circadian rhythm entrainment, sleep architecture, and chronobiology research
- Skeletal muscle metabolic programming and oxidative fiber capacity studies

### Technical Specifications

| Compound | SR9009 |
| --- | --- |
| Molecular Formula | C₂₃H₂₆ClN₃O₃S |
| Molecular Weight | ~480.0 Da |
| CAS Number | 1379686-30-2 |
| Mechanism | Rev-Erb α/β Nuclear Receptor Agonist |
| Purity | ≥98% (supplier specification) |
| Form | Oral tablet (10mg) |
| Quantity | 100 tablets per bottle |
| Storage | Cool, dry place away from heat, moisture and direct light |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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