# Selank – 10mg/vial (Research Use Only)

### Overview

Selank is a synthetic heptapeptide anxiolytic developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Derived from the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension to improve metabolic stability, Selank has been researched primarily in neuropsychopharmacology, with published work examining its interactions with GABAergic, serotoninergic, and dopaminergic systems alongside immune-modulating and neurotrophic effects. It holds regulatory status in Russia as an anxiolytic agent, providing a clinical and preclinical research base.

### What It Is

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, MW approximately 751 Da, CAS number 129954-34-3. It is structurally based on tuftsin (TKPR, a natural Fc receptor-derived peptide) extended by Pro-Gly-Pro at the C-terminus. Published research has examined Selank’s modulation of GABAergic neurotransmission (without direct GABAA receptor binding), BDNF expression, serotonin transporter activity, and enkephalin stability via metalloprotease inhibition.

### Key Research Applications

- Anxiolytic pharmacology and GABAergic modulation research without direct GABAA receptor binding
- BDNF expression and neurotrophic factor regulation studies in stress models
- Serotonin transporter (SERT) activity and serotonergic system modulation research
- Enkephalin degradation inhibition and endogenous opioid system research
- Immunomodulatory research — tuftsin receptor interactions and macrophage activity studies
- Stress response, HPA axis modulation, and anxiety behavioral pharmacology in rodent models
- Cognitive function and learning/memory biomarker studies
- Comparative research vs. benzodiazepine class and other GABAergic anxiolytics

### Technical Specifications

| Amino Acids | 7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) |
| --- | --- |
| Molecular Weight | ~751 Da |
| CAS Number | 129954-34-3 |
| Parent Peptide | Tuftsin (TKPR) + Pro-Gly-Pro extension |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 10mg |
| Storage | −4 °F long-term |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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