# SS-31 (Elamipretide) – 50mg/vial — Research Use Only

Backed by the Research [Read: How Incretin and Growth-Hormone-Axis Compounds in the Literature →](https://portaltowellness.net/research/glp1-adjunct-peptide-research-guide/)

### Overview

SS-31 (Szeto-Schiller Peptide 31, also known as Elamipretide or MTP-131) is a synthetic mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane where it interacts with cardiolipin — the signature phospholipid of the mitochondrial inner membrane. By stabilizing cardiolipin’s interaction with cytochrome c and Complex IV of the electron transport chain, SS-31 has been studied in published research as a tool for examining mitochondrial cristae integrity, electron transport chain efficiency, and mitochondrial reactive oxygen species (mitoROS) generation. Its clinical development as Elamipretide in heart failure and Barth syndrome has produced a substantial published pharmacology literature.

### What It Is

SS-31 is a synthetic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2’6′-dimethyltyrosine), MW approximately 639 Da, CAS number 736992-21-5. The alternating aromatic and basic amino acid residues produce a net positive charge that drives electrostatic accumulation in the inner mitochondrial membrane, concentrating the peptide ~1000-fold relative to cytoplasm without dependence on mitochondrial membrane potential. The Dmt residue’s electron-rich phenol ring is responsible for cardiolipin interaction and the peptide’s radical-scavenging activity.

### Key Research Applications

- Cardiolipin-targeting and inner mitochondrial membrane stabilization research
- Cytochrome c retention, electron transport chain efficiency, and ATP synthesis studies
- Mitochondrial reactive oxygen species (mitoROS) suppression mechanism research
- Mitochondrial cristae morphology and membrane potential studies
- Heart failure, cardiac ischemia-reperfusion injury, and cardiomyocyte survival research
- Barth syndrome and cardiolipin deficiency disease modeling
- Age-related mitochondrial dysfunction and energy metabolism research
- Kidney ischemia-reperfusion and acute kidney injury preclinical modeling

### Technical Specifications

| Amino Acids | 4 (D-Arg-Dmt-Lys-Phe-NH₂) |
| --- | --- |
| Molecular Weight | ~639 Da |
| CAS Number | 736992-21-5 |
| Also Known As | Elamipretide; MTP-131; Bendavia |
| Mechanism | Cardiolipin-Targeted Mitochondrial Membrane Stabilizer |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 50mg |
| Storage | −4 °F long-term |

**Regulatory update — August 2026:** Elamipretide received FDA accelerated approval as **Forzinity** (elamipretide HCl) on September 19, 2025, for a single narrow indication: improving muscle strength in Barth syndrome patients weighing at least 30kg. This is the first mitochondria-targeted therapy to reach FDA approval. That approval does not extend to longevity, general mitochondrial support, insulin sensitivity, or any other use. The SS-31 sold on this page is a separate, unaffiliated research-use product — it carries no FDA approval of its own. See our [mitochondrial peptide comparison](https://portaltowellness.net/research/mitochondrial-peptide-comparison-ss31-mots-c-nad/) for more detail.

FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

Not sure which compounds fit your research? [Browse the Research Hub →](https://portaltowellness.net/research/)

Research Library

- [Overlapping Pathways in Circadian, Repair and Mitochondrial Biology](https://portaltowellness.net/research/sleep-repair-energy-one-system/)
- [Mitochondrial Peptide Comparison: SS-31, MOTS-c, and NAD+](https://portaltowellness.net/research/mitochondrial-peptide-comparison-ss31-mots-c-nad/)

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Source: https://portaltowellness.net/shop/ss-31/
Research use only. Terms: https://portaltowellness.net/research-use-only/