# Tesofensine – 500mcg × 100 tablets (Research Use Only)

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### Overview

Tesofensine is a triple monoamine reuptake inhibitor originally developed by NeuroSearch A/S for investigational use in neurodegenerative disease research and subsequently studied in metabolic science. By inhibiting the reuptake of all three major catecholamines — dopamine, norepinephrine, and serotonin — tesofensine has generated published research interest in reward circuitry, appetite regulation mechanisms, and central nervous system energy homeostasis modeling.

### What It Is

Tesofensine (NS2330) is a phenyltropane derivative with molecular formula C₁₇H₂₄ClNO (as HCl salt), MW approximately 312.84 Da, CAS number 195875-84-4. It inhibits the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT) with varying affinities, producing a broad monoaminergic signal amplification profile distinct from single-target reuptake inhibitors.

### Key Research Applications

- Triple monoamine reuptake inhibition pharmacology and receptor selectivity studies
- Central dopaminergic, noradrenergic, and serotonergic pathway modulation research
- Appetite and energy homeostasis regulatory mechanism studies in animal models
- Reward circuitry and mesolimbic dopamine system investigation
- Comparative pharmacology against single and dual monoamine reuptake inhibitors
- Neurodegenerative disease biomarker research (Parkinson’s and Alzheimer’s preclinical models)
- Metabolic rate, thermogenesis, and food intake regulation studies
- Central nervous system monoamine transporter occupancy and kinetics research

### Technical Specifications

| Compound | Tesofensine (NS2330) |
| --- | --- |
| Molecular Weight | ~312.84 Da (free base) |
| CAS Number | 195875-84-4 |
| Mechanism | Triple DAT/NET/SERT Reuptake Inhibitor |
| Purity | ≥98% (supplier specification) |
| Form | Oral tablet (500mcg) |
| Quantity | 100 tablets per bottle |
| Storage | Room temperature, away from moisture and light |

**FOR RESEARCH USE ONLY.** Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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