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Glossary: NNMT Inhibitors

What are NNMT Inhibitors?

Nicotinamide N‑methyltransferase (NNMT) is an enzyme that methylates nicotinamide, influencing NAD+ salvage pathways and cellular metabolism. NNMT inhibitors are compounds that block this enzyme’s activity, allowing researchers to study how altered methylation impacts energy balance, metabolic rate and cellular signalling.

Research Applications

  • Investigating the regulation of NAD+ synthesis and nicotinamide metabolism.
  • Modelling metabolic disorders, obesity and insulin resistance.
  • Exploring mechanisms of ageing, sirtuin activity and mitochondrial function.

Research Use Only

Related on Portal to Wellness5-Amino-1MQ 50mg vial · Browse the Research Hub

This glossary entry is provided for educational and research discussion purposes. Compounds discussed are intended exclusively for laboratory research and are not for human or animal consumption. This information does not constitute medical advice.

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