Research Briefs

The FDA withdrew its NMN exclusion in letters dated 29 September 2025. The New Dietary Ingredient notification requirement survived intact, and that is the part that decides whether a given product is lawful.

Branded, generic, authorised copy, compounded and research-use-only are five different regulatory pathways, not five words for the same thing. What each label actually means, and where Portal to Wellness sits.

Genentech licensed Hanmi’s UCN2 analog HM17321 in a deal worth up to $2.3 billion. What the compound is, what the animal data actually showed, and why a large licensing deal is not clinical evidence.

Evidence & Research Status Evidence LevelExtensive Human Clinical Data FDA StatusNot FDA-approved for human use Regulatory StatusResearch Use Only (RUO)

Evidence & Research Status Evidence LevelExtensive Human Clinical Data FDA StatusNot FDA-approved for human use Regulatory StatusResearch Use Only (RUO)

Evidence & Research Status Evidence LevelPreclinical / Early-Stage Research FDA StatusNot FDA-approved for human use Regulatory StatusResearch Use Only (RUO)

Evidence & Research Status Evidence LevelPreclinical / Early-Stage Research FDA StatusNot FDA-approved for human use Regulatory StatusResearch Use Only (RUO)

Evidence & Research Status Evidence LevelExtensive Human Clinical Data FDA StatusNot FDA-approved for human use Regulatory StatusResearch Use Only (RUO)

Evidence & Research Status Evidence LevelExtensive Human Clinical Data FDA StatusNot FDA-approved for human use Regulatory StatusResearch Use Only (RUO)