GABA – 100mg/vial (Research Use Only)

Overview

GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, mediating approximately 30–40% of all CNS synaptic transmission through ionotropic GABA-A and GABA-C receptors and metabotropic GABA-B receptors. As the endogenous agonist for the most pharmacologically significant inhibitory receptor system in the brain — the target of benzodiazepines, barbiturates, neurosteroids, and general anesthetics — GABA is among the most extensively researched neurotransmitters in pharmacology. Research interest also extends to peripheral GABA receptor systems, including pancreatic beta-cell GABA signaling and immune cell GABA receptor biology.

What It Is

GABA (4-aminobutanoic acid) is a non-proteinogenic amino acid with molecular formula C₄H₉NO₂, MW approximately 103.12 Da, CAS number 56-12-2. It is synthesized from L-glutamate by glutamic acid decarboxylase (GAD) using pyridoxal phosphate (vitamin B6) as cofactor, and catabolized via the GABA shunt (GABA transaminase → succinic semialdehyde → succinate entering TCA cycle). GABA-A receptor activation directly increases Cl⁻ conductance, hyperpolarizing the neuronal membrane. GABA-B receptor activation (Gi-coupled) reduces cAMP and modulates K⁺ and Ca²⁺ channels.

Key Research Applications

• GABA-A receptor pharmacology — chloride channel gating, subunit composition, and allosteric modulator research
• GABA-B receptor (Gi-coupled) signaling, presynaptic inhibition, and K⁺/Ca²⁺ channel modulation studies
• GABAergic synapse formation, GABA transporter (GAT1-4) expression, and reuptake studies
• Glutamate/GABA balance and excitatory/inhibitory neurotransmission research
• Pancreatic beta-cell GABA signaling and paracrine regulation of glucagon secretion studies
• Immune cell GABA receptor expression and immunomodulatory function research
• Anxiolytic and sedative mechanism studies — GABA-A receptor subunit selectivity research
• GABA shunt metabolism, TCA cycle integration, and neuroenergetics studies

Technical Specifications

FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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