What is the mTOR Pathway?
The mechanistic target of rapamycin (mTOR) pathway is a central signalling network that integrates nutrient availability, growth factors, and cellular energy status to regulate protein synthesis, autophagy, and cell growth. Researchers study the mTOR pathway to understand how its activation and inhibition influence metabolism, aging, and disease states.
Research Applications
- Exploring mechanisms of cell growth, protein synthesis, and autophagy.
- Investigating how nutrient and energy signals regulate mTOR complex 1 (mTORC1) and mTORC2 activity.
- Studying the effects of mTOR inhibitors like rapamycin and sirolimus on lifespan and metabolic health.
- Modeling diseases linked to dysregulated mTOR signalling, such as cancer, neurodegeneration, and metabolic disorders.
Research Use Only
This glossary entry is provided for educational and research discussion purposes. Compounds and pathways discussed are intended exclusively for laboratory research and are not for human or animal consumption. This information does not constitute medical advice.