15% OFF Sirolimus (Rapamycin) – 5mg × 10 tablets (Research Use Only)
Sirolimus (rapamycin), an mTORC1 inhibitor used as a reference compound in nutrient-sensing, autophagy and ageing research. Supplied for laboratory research and identification purposes only.
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3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
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Overview
Sirolimus (rapamycin) is one of the most significant compounds in modern longevity and cellular biology research. Originally isolated from Streptomyces hygroscopicus bacteria discovered on Easter Island (Rapa Nui), sirolimus is the prototypical mTOR (mechanistic target of rapamycin) pathway inhibitor. The mTOR signaling node integrates cellular nutrient sensing, growth factor signals, and energy status to regulate protein synthesis, autophagy, and cellular aging programs. Rapamycin’s ability to extend lifespan in multiple model organisms — including mice — has made it the reference compound in translational longevity biology.
What It Is
Sirolimus is a macrolide compound (molecular formula C₅₁H₇₉NO₁₃, MW ~914.17 Da, CAS number 53123-88-9) that acts as an allosteric inhibitor of mTORC1 by forming a gain-of-function complex with the FK506-binding protein FKBP12. This FKBP12-rapamycin complex then binds and inhibits mTOR’s kinase activity toward S6K1 and 4E-BP1. Sirolimus is FDA-approved as an immunosuppressant (Rapamune), providing a substantial human clinical pharmacokinetics literature.
Key Research Applications
- mTORC1 pathway inhibition and nutrient-sensing signaling research
- Autophagy induction, mitophagy, and cellular quality control mechanism studies
- Lifespan extension modeling in yeast, C. elegans, Drosophila, and rodent systems
- Immunosuppression pharmacology and T-cell/B-cell proliferation inhibition research
- Caloric restriction mimetic and longevity biology pathway studies
- S6K1 and 4E-BP1 phosphorylation dynamics and protein synthesis regulation research
- Cancer biology — mTOR pathway dysregulation and antiproliferative mechanism studies
- FKBP12 protein interaction, rapamycin-analog (rapalog) comparative pharmacology
Technical Specifications
| Compound | Sirolimus (Rapamycin) |
| Molecular Formula | C₅₁H₇₉NO₁₃ |
| Molecular Weight | ~914.17 Da |
| CAS Number | 53123-88-9 |
| Mechanism | mTORC1 Allosteric Inhibitor (FKBP12-dependent) |
| Purity | ≥98% (supplier specification) |
| Form | Oral tablet (5mg) |
| Quantity | 10 tablets per pack |
| Storage | Cool, dry place away from heat, moisture and direct light |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
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- Store in a cool, dry place away from heat, moisture and direct light
- Keep the container tightly closed
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