Definition: Sirtuins are a family of NAD+-dependent deacetylases (SIRT1–SIRT7) that regulate gene expression, metabolism, and stress responses through removal of acetyl groups from histones and other proteins.
Research overview: Studies of sirtuin pathways investigate how these enzymes influence mitochondrial biogenesis, metabolic health, aging, inflammation, and cellular stress resilience. Researchers examine how activating or inhibiting specific sirtuins modulates pathways such as AMPK, mTOR, and FOXO, and their roles in longevity, neuroprotection, and metabolic regulation.
Applications in research:
- Exploring the molecular mechanisms of lifespan extension and caloric restriction mimetics
- Investigating the link between sirtuin activity, metabolic disorders, and inflammatory pathways
- Developing modulators of SIRT1-7 for in vitro studies of neurodegenerative disease, cancer, and metabolic syndrome
- Understanding the interplay between sirtuin signaling, autophagy, and mitochondrial function
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