15% OFF Glutathione – 1500mg/vial (Research Use Only)
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3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
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Overview
Glutathione (GSH) is the most abundant intracellular antioxidant and the master regulator of cellular redox homeostasis in mammalian biology. This tripeptide (Gly-Cys-Glu, with the gamma-peptide bond linking glutamate to cysteine) is synthesized in all mammalian cells and serves as the principal substrate for glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutaredoxin enzyme systems — collectively responsible for neutralizing reactive oxygen species, reactive nitrogen species, lipid peroxides, and electrophilic xenobiotics. Research into glutathione dynamics spans cancer biology, aging, neurodegeneration, liver pharmacology, and immune function.
What It Is
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) has the molecular formula C₁₀H₁₇N₃O₆S, MW ~307.32 Da, CAS number 70-18-8. The gamma-peptide bond at the glutamyl-cysteine junction makes GSH resistant to most peptidases, enabling cytoplasmic stability. The cysteine thiol group (-SH) is the chemically active site responsible for oxidant neutralization, forming glutathione disulfide (GSSG) upon oxidation. The GSH:GSSG ratio is a widely used research marker of cellular redox state.
Key Research Applications
- Cellular redox homeostasis and GSH:GSSG ratio measurement research
- Glutathione peroxidase (GPx) and glutathione reductase enzyme activity studies
- Glutathione S-transferase (GST) xenobiotic conjugation and phase II detoxification research
- Oxidative stress modeling — ROS and lipid peroxide neutralization studies
- Liver pharmacology and hepatic detoxification pathway research
- Mitochondrial membrane potential, oxidative phosphorylation, and antioxidant defense studies
- Neurodegeneration modeling — GSH depletion in Parkinson’s and Alzheimer’s disease research
- Immune cell function — T-cell and NK cell activity in relation to GSH status studies
Technical Specifications
| Compound | L-Glutathione (GSH, reduced form) |
| Molecular Formula | C₁₀H₁₇N₃O₆S |
| Molecular Weight | ~307.32 Da |
| CAS Number | 70-18-8 |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder (injectable grade) |
| Vial Size | 1,500mg |
| Storage | −4 °F long-term |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
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- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
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