15% OFF P21 – 5mg/vial (Research Use Only)
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3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
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Overview
P021 (also written P21) is a synthetic tetrapeptide derived from the CNTF (ciliary neurotrophic factor) binding site, designed to activate TrkB (tropomyosin receptor kinase B) — the high-affinity receptor for brain-derived neurotrophic factor (BDNF). By mimicking BDNF’s TrkB activation without engaging the pan-neurotrophin receptor p75NTR, P021 has been studied as a selective TrkB agonist tool compound in preclinical neuroscience research.
What It Is
P021 is a synthetic 4-amino acid peptide corresponding to the CNTF loop-4 region responsible for TrkB receptor interaction. MW approximately 390–430 Da. Its mechanism involves selective engagement of the TrkB ligand-binding domain, triggering downstream MAPK/ERK, PI3K/Akt, and PLCγ signaling cascades that mediate BDNF-like neurotrophic effects.
Key Research Applications
- TrkB receptor activation and BDNF signaling pathway research
- MAPK/ERK, PI3K/Akt, and PLCγ neurotrophin downstream signaling studies
- Synaptic plasticity, LTP, and dendritic spine density studies in rodent brain models
- Alzheimer’s disease preclinical modeling — tau phosphorylation and amyloid pathway research
- Neuronal survival, neurite outgrowth, and differentiation studies in cell culture systems
- Comparative TrkB agonist research vs. BDNF, NT-4, and other TrkB ligands
- CNS-penetrant small peptide pharmacokinetics and blood-brain barrier research
- Cognitive function biomarker studies in aged rodent models
Technical Specifications
| Type | Synthetic tetrapeptide (CNTF-derived TrkB agonist) |
| Molecular Weight | ~390–430 Da |
| Target Receptor | TrkB (BDNF high-affinity receptor) |
| Mechanism | Selective TrkB Agonist — MAPK/ERK, PI3K/Akt pathways |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 5mg |
| Quantity | 10 vials |
| Storage | −4 °F long-term |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
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- Processing: Orders ship within 1–2 business days
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- Free shipping on orders over $100
- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
Frequently Asked Questions
P21 is a peptide derived from ciliary neurotrophic factor (CNTF). In preclinical models it has been studied for effects on dendritic spine density and synaptic plasticity. Semax is a different compound, based on an ACTH fragment and studied in neurotrophin research. Neither has established human evidence for these effects.
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