CJC-1295 (No DAC) – 10mg/vial (Research Use Only)

Overview

CJC-1295 without DAC — also known in the published literature as Modified GRF 1-29 (Mod GRF 1-29) — is a stabilized synthetic analogue of the endogenous growth hormone-releasing hormone (GHRH). Engineered to resist rapid enzymatic degradation while retaining GHRH receptor binding selectivity, this peptide has become the leading research tool for studying pulsatile GH secretion pharmacology and GHRH receptor-mediated signaling. Its shorter half-life profile compared to the DAC-containing variant makes it the preferred compound for pulse-frequency research designs.

What It Is

CJC-1295 (No DAC) is a 29-amino acid synthetic analogue of GHRH(1-29) incorporating four strategic amino acid substitutions at positions 2, 8, 15, and 27 that confer proteolytic resistance to dipeptidyl peptidase IV and other plasma peptidases. Its molecular weight is approximately 3,368 Da. Without the Drug Affinity Complex (DAC) — the lysine-reactive chemical modification that covalently binds the peptide to albumin — CJC-1295 (No DAC) has a plasma half-life profile suitable for research into pulsatile GH release kinetics.

Research Spotlight

Published research on CJC-1295 (No DAC) / Mod GRF 1-29 has established it as the primary synthetic GHRH tool for studying growth hormone secretagogue pharmacology. Receptor binding studies have characterized its affinity and selectivity at the GHRH receptor (GHRHR) using radioligand competition assays and functional cAMP accumulation assays in GHRHR-expressing cell systems. Pituitary pharmacology research has documented GH secretion dose-response relationships in rodent and porcine in vivo models, with investigators characterizing the amplitude and pulse frequency of GH release following administration.

Pharmacodynamic research has compared CJC-1295 (No DAC) to native GHRH(1-29), GHRH(1-44), and the DAC-containing CJC-1295 analogue, documenting distinct half-life and GH pulse profiles across these compounds. The combination of CJC-1295 (No DAC) with ghrelin receptor agonists such as Ipamorelin has been extensively documented in the published literature as a model system for studying the synergistic GH-amplifying effects of combined GHRH/ghrelin receptor co-stimulation.

Key Research Applications

• GHRH receptor binding affinity and selectivity characterization
• Pulsatile GH secretion kinetics and dose-response modeling in animal models
• Pharmacokinetic comparison of GHRH analogues (No DAC vs. DAC variants)
• Synergistic GH release studies in combination with ghrelin receptor agonists (Ipamorelin, GHRP-2)
• IGF-1 axis downstream response measurement in animal models
• Pituitary somatotroph cell function and desensitization research
• Growth hormone secretagogue receptor cross-talk investigations
• Half-life engineering and proteolytic stability research in peptide design

Purity & Quality

Portal to Wellness CJC-1295 (No DAC) is lyophilized to ≥98% purity (supplier specification), 10mg vial format. This compound is frequently paired with Ipamorelin for combination GH secretagogue research — both are available individually in the Portal to Wellness catalog.

Competitor Research Notes

The GHRH analogue market has many entries; key differentiation is purity documentation and the absence of reactive DAC modification byproducts. Researchers comparing CJC-1295 (No DAC) to CJC-1295 (with DAC) should note that the No DAC variant provides pulse-frequency control that is not achievable with the long-acting DAC form — an important mechanistic consideration for study design. Vial size and price-per-mg should be evaluated against purity-verified batches only.

Technical Specifications

FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.

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