15% OFF NAD+ – 1,000mg/vial — Research Use Only
NAD+ at high concentration for cellular-energy research. ≥98% purity. Research use only.
Availability: In stock
3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
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NAD+ – 1,000mg/vial
Compare NAD+ Sizes
Same compound, three vial sizes. Larger vials carry a meaningfully lower cost per mg.
| Product | Concentration | Price | Price / mg |
|---|---|---|---|
| NAD+ 100mg | 100mg/vial | $39.00 | $0.39 |
| NAD+ 500mg | 500mg/vial | $65.00 | $0.13 |
| NAD+ 1,000mgLowest $/mg | 1,000mg/vial | $95.00 | $0.095 |
Nicotinamide adenine dinucleotide (NAD+) is an endogenous dinucleotide coenzyme found in all living cells, participating as an electron carrier in oxidation-reduction reactions central to cellular energy metabolism. Its molecular weight is approximately 663 Da (free acid form). NAD+ exists in oxidized (NAD+) and reduced (NADH) forms and serves as a substrate for several classes of enzymes including sirtuins, PARPs, and CD38/CD157 ectoenzymes. This high-concentration 1,000mg vial is intended for laboratory and research applications.
Research Background
Published laboratory research has extensively examined NAD+ in the context of cellular bioenergetics, mitochondrial function, and aging biology. Investigators have studied NAD+ metabolism and its relationship to sirtuin deacetylase activity in cell culture and animal models. Research has explored the role of NAD+ as a substrate for poly(ADP-ribose) polymerases (PARPs) in DNA damage response studies. Published in vivo studies have examined NAD+ precursor supplementation effects on tissue NAD+ levels and metabolic parameters in rodent models. Research using cell-free and cell-based systems has also investigated NAD+-dependent signaling in models of senescence and metabolic regulation.
Technical Specifications
| Compound | β-Nicotinamide adenine dinucleotide (oxidized) |
| Molecular Weight | ~663 Da |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 1,000mg |
| Storage | −4 °F long-term |
For research use only. Not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition.
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Frequently Asked Questions — NAD+
What is NAD+ and why is it central to cellular energy and aging research?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in all living cells, functioning as an essential electron carrier in the mitochondrial electron transport chain. It is also a required substrate for sirtuins (SIRT1–7), the deacetylase enzymes central to longevity research, and for PARP enzymes involved in DNA repair. Tissue NAD+ levels have been reported to decline with age, which is why NAD+ metabolism is a major topic in ageing research.
How does NAD+ activate sirtuin pathways?
Sirtuins require NAD+ as a co-substrate to function — they cannot operate without adequate NAD+ availability. When NAD+ levels are sufficient, SIRT1 deacetylates PGC-1α (driving mitochondrial biogenesis), SIRT3 maintains mitochondrial protein homeostasis, and SIRT6 supports DNA repair fidelity. Low NAD+ concentrations effectively silence these pathways. This mechanism is why sirtuin activation and NAD+ research are inseparable in longevity science.
What is the difference between NAD+, NMN, and NR as research compounds?
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors that are converted to NAD+ intracellularly after absorption. How extracellular NAD+ reaches the intracellular pool is itself an open research question.
Why are there three NAD+ vial sizes?
Vial size is a quantity of material, not a stage in a programme. All three contain the same compound. Portal to Wellness does not publish protocols, combinations or quantities, and nothing on this page is a recommendation for use.
What has published NAD+ research examined?
Published research has examined NAD+ metabolism in cell, animal and small human studies. Portal to Wellness does not publish amounts, schedules or administration routes for any compound. This product is not for human use.
Related research (educational)
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- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
Frequently Asked Questions
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in all living cells. It carries electrons in the mitochondrial electron transport chain and is a required substrate for sirtuins (SIRT1–7) and PARP enzymes. Tissue NAD+ levels have been reported to decline with age, which is why NAD+ metabolism is a major topic in ageing research.
Sirtuins use NAD+ as a co-substrate, so their activity depends on NAD+ availability. SIRT1 deacetylates PGC-1α, SIRT3 regulates mitochondrial protein acetylation, and SIRT6 is involved in DNA repair.
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors that cells convert to NAD+. How extracellular NAD+ itself reaches the intracellular pool is an open research question.
Vial size is a quantity of material, not a stage in a programme. All three contain the same compound. Portal to Wellness does not publish protocols, combinations or quantities, and nothing on this page is a recommendation for use.
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