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Dutasteride – 1mg × 100 tablets (Research Use Only)
Dutasteride, a dual type I and type II 5α-reductase inhibitor used as a reference compound in androgen and DHT signalling research. Supplied for laboratory research and identification purposes only.
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Overview
Dutasteride is a dual 5-alpha reductase inhibitor (5-ARI) that blocks both type 1 and type 2 isoforms of the enzyme responsible for converting testosterone to dihydrotestosterone (DHT). While finasteride (a selective type 2 inhibitor) has long been the reference 5-ARI in androgen research, dutasteride’s dual-isoform inhibition produces more complete systemic DHT suppression, making it a valuable comparative research tool for dissecting the relative contributions of type 1 and type 2 5-alpha reductase to androgenic signaling in different tissues.
What It Is
Dutasteride is a synthetic 4-azasteroid compound with molecular formula C₂₇H₃₀F₆N₂O₂, MW ~528.53 Da, CAS number 164656-23-9. It is a competitive inhibitor of both 5α-reductase type 1 (predominantly expressed in skin, liver, and brain) and type 2 (predominantly expressed in prostate, seminal vesicles, and hair follicles). Published pharmacokinetics data document a plasma half-life of approximately 5 weeks.
Key Research Applications
- Dual 5α-reductase (type 1 and 2) inhibition pharmacology and selectivity studies
- Dihydrotestosterone (DHT) suppression and androgen signaling pathway research
- Prostate biology — BPH modeling, androgen receptor activation, and prostate tissue studies
- Androgenetic alopecia mechanistic research and hair follicle androgen sensitivity studies
- Comparative pharmacology vs. finasteride (type 2 selective) in DHT suppression models
- Neurosteroid metabolism — allopregnanolone and neuroactive steroid pathway research
- Adrenal androgen (DHEA, androstenedione) conversion pathway studies
- Long-acting 5-ARI pharmacokinetics and tissue DHT distribution research
Technical Specifications
| Compound | Dutasteride |
| Molecular Formula | C₂₇H₃₀F₆N₂O₂ |
| Molecular Weight | ~528.53 Da |
| CAS Number | 164656-23-9 |
| Mechanism | Dual 5α-Reductase Type 1 & 2 Inhibitor |
| Purity | ≥98% (supplier specification) |
| Form | Oral tablet (1mg) |
| Quantity | 100 tablets per bottle |
| Storage | Room temperature, away from moisture and light |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
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- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
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- Store in a cool, dry place away from heat, moisture and direct light
- Keep the container tightly closed
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