15% OFF Humanin – 10mg/vial (Research Use Only)
Humanin, a mitochondrial-derived peptide studied in apoptosis and mitochondrial signalling research. Supplied for laboratory research and identification purposes only.
Availability: In stock
3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
Applied automatically in the cart. Combines with a discount code up to 20% off in total, and stacks on top of the subscription discount.
Research Disclaimer: All products currently listed on this site are for research purposes only.
Overview
Humanin is a 21-amino acid mitochondria-derived peptide (MDP) encoded within the 16S ribosomal RNA gene of the mitochondrial genome. First identified in research examining neuronal survival in Alzheimer’s disease models, humanin has accumulated a published literature spanning neuroprotection, metabolic biology, cardiovascular research, and longevity science. Its discovery opened a research frontier examining how mitochondria communicate with the nucleus, other organelles, and distant tissues through secreted peptide signals.
What It Is
Humanin (HN) is a 21-amino acid peptide encoded within the mitochondrial 16S rRNA gene. MW approximately 2,586 Da, CAS number 330936-46-4. It signals through a receptor complex involving CNTFR/WSX-1/gp130 and also directly interacts with pro-apoptotic proteins including IGFBP-3, Bax, and tBid intracellularly. Humanin is secreted into the bloodstream and detected in human plasma, with levels declining with age.
Key Research Applications
- Mitochondria-derived peptide (MDP) signaling and mitochondrial-nuclear communication research
- Neuroprotection and amyloid-beta toxicity inhibition studies in Alzheimer’s preclinical models
- Anti-apoptotic mechanism research — Bax, IGFBP-3, and tBid interaction studies
- gp130/CNTFR/WSX-1 receptor complex activation and STAT3 pathway research
- Mitochondrial function, bioenergetics, and aging biology studies
- Insulin sensitivity, glucose metabolism, and pancreatic beta-cell survival research
- Cardiovascular protection — cardiac apoptosis and ischemia-reperfusion injury modeling
- Age-related MDP decline and longevity marker correlation studies
Technical Specifications
| Amino Acids | 21 |
| Molecular Weight | ~2,586 Da |
| CAS Number | 330936-46-4 |
| Origin | Mitochondrial 16S rRNA gene-encoded peptide |
| Mechanism | gp130/CNTFR/WSX-1 agonism; anti-apoptotic interactions |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 10mg |
| Storage | −4 °F long-term |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
Not sure which compounds fit your research? Browse the Research Hub →
Related research (educational)
- Processing: Orders ship within 1–2 business days
- Domestic delivery: 3–5 business days via USPS Priority / UPS Ground
- Free shipping on orders over $100
- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
Pairs Well With
Related research products
Reviews
There are no reviews yet.