15% OFF SS-31 (Elamipretide) – 50mg/vial — Research Use Only
Elamipretide, a mitochondria-targeted tetrapeptide investigated in published work for its binding affinity to cardiolipin and its effects on electron transport chain complexes. Supplied for laboratory research and identification purposes only.
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3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
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- Binds cardiolipin in the inner mitochondrial membrane — a structural mechanism distinct from antioxidant compounds
- Studied for mitochondrial membrane potential and ATP production in aged tissue models
- Human clinical trial data exists for elamipretide in heart failure
- Studied at the level of membrane structure rather than reactive oxygen species scavenging
- No hormonal activity or receptor competition documented in the published literature
Mechanism of Action
SS-31 (Szeto-Schiller 31) is a tetrapeptide that concentrates in the inner mitochondrial membrane, where it binds cardiolipin — a phospholipid critical for cristae architecture and electron transport chain efficiency. Published work describes stabilisation of cardiolipin and reduced cytochrome c dissociation, with effects on the structural integrity of oxidative phosphorylation complexes. Its mechanism is described as membrane-structural rather than ROS-scavenging.
Research Overview
The MMAD clinical trial evaluated exercise capacity and cardiac function with elamipretide (SS-31) in heart failure patients. Animal studies report restoration of mitochondrial membrane potential and ATP production in aged skeletal muscle, kidney protection in ischaemia-reperfusion injury, and cognitive endpoints in neurodegeneration models. The mechanism studied is structural membrane binding rather than ROS scavenging.
Research & Stack Notes
SS-31 and MOTS-c act through different described mechanisms — membrane structure versus AMPK-mediated metabolic signalling. No adverse interactions with other research compounds are documented in the published literature.
Educational purposes only. Research use. Not evaluated by the FDA.
Overview
SS-31 (Szeto-Schiller Peptide 31, also known as Elamipretide or MTP-131) is a synthetic mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane where it interacts with cardiolipin — the signature phospholipid of the mitochondrial inner membrane. By stabilizing cardiolipin’s interaction with cytochrome c and Complex IV of the electron transport chain, SS-31 has been studied in published research as a tool for examining mitochondrial cristae integrity, electron transport chain efficiency, and mitochondrial reactive oxygen species (mitoROS) generation. Its clinical development as Elamipretide in heart failure and Barth syndrome has produced a substantial published pharmacology literature.
What It Is
SS-31 is a synthetic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2’6′-dimethyltyrosine), MW approximately 639 Da, CAS number 736992-21-5. The alternating aromatic and basic amino acid residues produce a net positive charge that drives electrostatic accumulation in the inner mitochondrial membrane, concentrating the peptide ~1000-fold relative to cytoplasm without dependence on mitochondrial membrane potential. The Dmt residue’s electron-rich phenol ring is responsible for cardiolipin interaction and the peptide’s radical-scavenging activity.
Key Research Applications
- Cardiolipin-targeting and inner mitochondrial membrane stabilization research
- Cytochrome c retention, electron transport chain efficiency, and ATP synthesis studies
- Mitochondrial reactive oxygen species (mitoROS) suppression mechanism research
- Mitochondrial cristae morphology and membrane potential studies
- Heart failure, cardiac ischemia-reperfusion injury, and cardiomyocyte survival research
- Barth syndrome and cardiolipin deficiency disease modeling
- Age-related mitochondrial dysfunction and energy metabolism research
- Kidney ischemia-reperfusion and acute kidney injury preclinical modeling
Technical Specifications
| Amino Acids | 4 (D-Arg-Dmt-Lys-Phe-NH₂) |
| Molecular Weight | ~639 Da |
| CAS Number | 736992-21-5 |
| Also Known As | Elamipretide; MTP-131; Bendavia |
| Mechanism | Cardiolipin-Targeted Mitochondrial Membrane Stabilizer |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 50mg |
| Storage | −4 °F long-term |
Regulatory update — August 2026: Elamipretide received FDA accelerated approval as Forzinity (elamipretide HCl) on September 19, 2025, for a single narrow indication: improving muscle strength in Barth syndrome patients weighing at least 30kg. This is the first mitochondria-targeted therapy to reach FDA approval. That approval does not extend to longevity, general mitochondrial support, insulin sensitivity, or any other use. The SS-31 sold on this page is a separate, unaffiliated research-use product — it carries no FDA approval of its own. See our mitochondrial peptide comparison for more detail.
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
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- Processing: Orders ship within 1–2 business days
- Domestic delivery: 3–5 business days via USPS Priority / UPS Ground
- Free shipping on orders over $100
- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
Frequently Asked Questions
SS-31 (elamipretide) is a tetrapeptide that concentrates in the inner mitochondrial membrane, where it binds cardiolipin, a phospholipid involved in organising the electron transport chain. It is studied in mitochondrial biology and has been evaluated in human trials, with mixed results. Portal to Wellness does not publish protocols, combinations or quantities, and nothing on this page is a recommendation for use.
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