15% OFF Selank – 10mg/vial (Research Use Only)
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3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
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- Studied for anxiolytic activity in preclinical and Russian clinical literature
- Modulates GABAergic transmission through a mechanism distinct from benzodiazepines
- Reported effects on BDNF and serotonin turnover in preclinical models
- Investigated as both an anxiolytic and a nootropic in published literature since the 1990s
- Published primarily in Russian-language literature, with limited independent replication
Mechanism of Action
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic analogue of the endogenous tuftsin peptide, extended with a Pro-Gly-Pro sequence for stability. Published work describes modulation of GABAergic transmission and inhibition of enkephalin-degrading enzymes, at sites distinct from benzodiazepine binding. It is also reported to affect BDNF and TRKB expression, serotonin turnover, and immune signalling. Human evidence outside the Russian-language literature is limited.
Research Overview
Russian clinical trials compared Selank against established anxiolytics on standardised anxiety measures. Cognitive studies report effects on memory consolidation and sustained attention. Immunomodulatory effects — upregulation of IL-6 and interferon expression — are reported in the same literature. This body of work has limited independent replication outside Russia.
Research & Stack Notes
Selank and Semax are frequently examined together in the published cognitive literature, acting on different pathways. No compound interactions are documented in that literature.
Educational purposes only. Research use. Not evaluated by the FDA.
Overview
Selank is a synthetic heptapeptide anxiolytic developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Derived from the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension to improve metabolic stability, Selank has been researched primarily in neuropsychopharmacology, with published work examining its interactions with GABAergic, serotoninergic, and dopaminergic systems alongside immune-modulating and neurotrophic effects. It holds regulatory status in Russia as an anxiolytic agent, providing a clinical and preclinical research base.
What It Is
Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, MW approximately 751 Da, CAS number 129954-34-3. It is structurally based on tuftsin (TKPR, a natural Fc receptor-derived peptide) extended by Pro-Gly-Pro at the C-terminus. Published research has examined Selank’s modulation of GABAergic neurotransmission (without direct GABAA receptor binding), BDNF expression, serotonin transporter activity, and enkephalin stability via metalloprotease inhibition.
Key Research Applications
- Anxiolytic pharmacology and GABAergic modulation research without direct GABAA receptor binding
- BDNF expression and neurotrophic factor regulation studies in stress models
- Serotonin transporter (SERT) activity and serotonergic system modulation research
- Enkephalin degradation inhibition and endogenous opioid system research
- Immunomodulatory research — tuftsin receptor interactions and macrophage activity studies
- Stress response, HPA axis modulation, and anxiety behavioral pharmacology in rodent models
- Cognitive function and learning/memory biomarker studies
- Comparative research vs. benzodiazepine class and other GABAergic anxiolytics
Technical Specifications
| Amino Acids | 7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) |
| Molecular Weight | ~751 Da |
| CAS Number | 129954-34-3 |
| Parent Peptide | Tuftsin (TKPR) + Pro-Gly-Pro extension |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 10mg |
| Storage | −4 °F long-term |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
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- Free shipping on orders over $100
- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
Frequently Asked Questions
Both are synthetic peptides developed in Russia. Semax is based on an ACTH fragment and is studied in neurotrophin (BDNF/NGF) research. Selank is an analogue of the peptide tuftsin and is studied in GABAergic and enkephalinase research. Portal to Wellness supplies each as a single research compound and does not recommend combining them.
Selank is approved as a medicine in Russia. It is not FDA-approved, and this research-grade material is not for human use.
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