15% OFF LL37 – 5mg/vial (Research Use Only)
LL-37, the human cathelicidin host-defence peptide, studied in innate immunity, antimicrobial peptide and wound-biology research. Supplied for laboratory research and identification purposes only.
Availability: In stock
3–4 vials — 5% off · 5–9 vials — 10% off · 10+ vials — 15% off
Applied automatically in the cart. Combines with a discount code up to 20% off in total, and stacks on top of the subscription discount.
Research Disclaimer: All products currently listed on this site are for research purposes only.
Research FAQ
What is LL-37 studied for?
LL-37 is studied in innate-immunity research for antimicrobial activity, immune modulation, and wound-healing/angiogenesis signaling as the human cathelicidin peptide. Sold for research use only.
What kind of peptide is LL-37?
LL-37 is a cathelicidin-derived host-defense (antimicrobial) peptide — the only cathelicidin found in humans — making it central to innate-immunity research.
Overview
LL-37 is the sole member of the cathelicidin family of host-defense peptides expressed in humans, cleaved from the C-terminus of the precursor protein hCAP18 (human cationic antimicrobial protein 18). As the principal human cathelicidin, LL-37 has generated extensive published research across antimicrobial pharmacology, immunomodulation, wound healing biology, angiogenesis, and cancer biology. Its dual roles as a direct antimicrobial agent and an immunomodulatory signaling molecule — acting on FPR2/FPRL1, P2X7, and EGF receptor among other targets — make it one of the most mechanistically versatile research peptides in innate immunity.
What It Is
LL-37 is an amphipathic alpha-helical 37-amino acid peptide with the N-terminal sequence LL (Leu-Leu), cleaved from the C-terminal region of hCAP18 by serine protease (proteinase 3) processing. Molecular formula: C₂₀₅H₃₄₀N₆₀O₅₃S (approximate), MW approximately 4,493 Da, CAS number 154947-66-7. Its amphipathic alpha-helical structure enables membrane disruption of bacterial, fungal, and viral lipid membranes while also engaging eukaryotic cell surface receptors including FPR2/FPRL1, EGFR, and P2X7 purinergic receptor.
Key Research Applications
- Antimicrobial activity research — bacterial membrane disruption and MIC studies
- Host defense peptide biology and innate immunity research
- FPR2/FPRL1 and EGFR receptor activation and downstream signaling studies
- Wound healing research — epithelial cell migration, proliferation, and angiogenesis studies
- Anti-biofilm activity and anti-bacterial resistance mechanism research
- Immunomodulatory pathway research — macrophage, dendritic cell, and neutrophil activation
- Cancer biology — dual pro-apoptotic and pro-survival LL-37 effect research
- Antiviral mechanism studies — enveloped virus membrane interaction research
Technical Specifications
| Amino Acids | 37 (N-terminal Leu-Leu sequence) |
| Molecular Weight | ~4,493 Da |
| CAS Number | 154947-66-7 |
| Origin | Human cathelicidin CAMP gene product (hCAP18 C-terminal fragment) |
| Mechanism | Antimicrobial membrane disruptor; FPR2/FPRL1 and EGFR agonist |
| Purity | ≥98% (supplier specification) |
| Form | Lyophilized powder |
| Vial Size | 5mg |
| Storage | −4 °F long-term; avoid repeated freeze-thaw cycles |
FOR RESEARCH USE ONLY. Not intended for human or veterinary consumption, medical diagnosis, treatment, or prevention of any disease or condition. This product has not been evaluated by the FDA or any regulatory agency. Must be handled by qualified research personnel in a compliant laboratory setting. These statements have not been evaluated by the Food and Drug Administration.
Not sure which compounds fit your research? Browse the Research Hub →
- Processing: Orders ship within 1–2 business days
- Domestic delivery: 3–5 business days via USPS Priority / UPS Ground
- Free shipping on orders over $100
- Temperature handling: Cold-chain packaging available on request for lyophilized peptides
- Tracking: Emailed automatically at time of dispatch
- Store lyophilized (dry) peptides at −4 °F for long-term stability
- Protect from light and moisture at all times
- Do not freeze
- Where the Storage row in the product specification above differs, follow the specification
Pairs Well With
Related research products
Reviews
There are no reviews yet.